ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Improving the diagnosis of acute hepatitis C virus infection with expanded viral load criteria.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.Hepatology (Baltimore, Md.) · 2020Guideline
- CD4+ T cell restoration and control of hepatitis C virus replication after childbirth.The Journal of clinical investigation · 2020Trial
- Plasma interferon-gamma-inducible protein-10 (IP-10) levels during acute hepatitis C virus infection.Hepatology (Baltimore, Md.) · 2013Trial
- A simple strategy to identify acute hepatitis C virus infection among newly incarcerated injection drug users.Hepatology (Baltimore, Md.) · 2013Trial
- Detection of anti-HCV antibodies in the clinical classification and epidemiological surveillance of HCV infection.Molecular biology reports · 2025Review
- Acute Hepatitis C After Penile Stem Cell Injection.Cureus · 2022Article
- A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome.Clinical case reports · 2022Article
- T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy.Cold Spring Harbor perspectives in medicine · 2021Review
- The clinical impact of hepatitis C virus infection in Egyptian multiple myeloma patients.Journal of the Egyptian National Cancer Institute · 2020Observational
- Dried blood spot self-sampling at home is a feasible technique for hepatitis C RNA detection.PloS one · 2020Article
- Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study.Canadian journal of gastroenterology & hepatology · 2020Article
- Article
- Evaluation of the Aptima HCV Quant Dx Assay Using Serum and Dried Blood Spots.Journal of clinical microbiology · 2019Article
- Inhibition of Hepatitis C Virus Replication Induced by Chemotherapy: A Prospective Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Management of acute HCV infection in the era of direct-acting antiviral therapy.Nature reviews. Gastroenterology & hepatology · 2018Review
- Genotype-related variations in proinflammatory and regulatory cytokine levels in treated and treatment-naive HCV-infected patients.Medical microbiology and immunology · 2018Article
- Hepatitis C virus reactivation in patients receiving cancer treatment: A prospective observational study.Hepatology (Baltimore, Md.) · 2018Observational
- The oncologic burden of hepatitis C virus infection: A clinical perspective.CA: a cancer journal for clinicians · 2017Review
- Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundThe diagnosis of acute hepatitis C virus (HCV) infection is imprecise because antibody testing does not differentiate between acute and chronic infection. Although virologic features, such as viral load fluctuations and low levels of viremia, have been noted to be characteristic of acute HCV infection, these parameters have not been used for diagnosis.
methodsWe validated the use of these novel parameters (ie, viral load fluctuations >1 log and HCV RNA levels <100,000 IU/mL) in a cohort of acute HCV seroconverters. We then applied standard diagnostic criteria for acute HCV infection in a cohort of high-risk injection drug users entering prison with suspected acute HCV infection (n=37). We subsequently assessed whether these novel virologic parameters, measured serially over a 10-week period, could enhance the diagnosis of acute infection.
resultsLow-level viremia and viral load fluctuations were highly prevalent in our cohort of acute seroconverters (81% and 86%, respectively), whereas low-level viremia occurred in only 13% of control patients with chronic infection. With use of standard criteria, 37 inmates received a diagnosis of acute HCV infection. Among the 35 patients with HCV RNA detectable at baseline, we found low-level viremia to be highly prevalent (n=27; 77%); among patients with a minimum of 2 HCV RNA samples, we demonstrated viral fluctuations in more than one-third (n=9; 36%).
conclusionsThe diagnosis of acute infection in HCV-seropositive patients is strengthened by the use of virologic parameters that are uncommon in chronic disease. Viral load fluctuations and low levels of HCV RNA should be incorporated into standard diagnostic criteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.