ArticleJournal of biomedical optics
Optical approach to the salivary pellicle.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05470023 (Imaging-based Assessment of Oral Biofilm and Gingival Health), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging-based Assessment of Oral Biofilm and Gingival Health
Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Multimodality imaging of the effects of a novel dentifrice on oral biofilm.Lasers in surgery and medicine · 2014Trial
- Effect of Surface Modification of a Dental Composite on the Adhesion ofPathogens (Basel, Switzerland) · 2025Article
- Acquired pellicle engineering: a fascinating approach to prevent demineralization.Journal of applied oral science : revista FOB · 2025Review
- Potential Application of Non-Invasive Optical Imaging Methods in Orthodontic Diagnosis.Journal of clinical medicine · 2024Article
- Salivary pellicle modulates biofilm formation on titanium surfaces.Clinical oral investigations · 2023Article
- Application of three-dimensional reconstruction technology in dentistry: a narrative review.BMC oral health · 2023Review
- Acquired salivary pellicle and oral diseases: A literature review.Journal of dental sciences · 2021Review
- The Use of Optical Coherence Tomography in Dental Diagnostics: A State-of-the-Art Review.Journal of healthcare engineering · 2017Review
- Exploring Mechanisms of Biofilm Removal.Dentistry (Sunnyvale, Calif.) · 2016Article
- Biopolymeric Mucin and Synthetic Polymer Analogs: Their Structure, Function and Role in Biomedical Applications.Polymers · 2016Review
- Synthetic oral mucin mimic from polymer micelle networks.Biomacromolecules · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The salivary pellicle plays an important role in oral physiology, yet noninvasive in situ characterization and mapping of this layer remains elusive. The goal of this study is to develop an optical approach for the real-time, noninvasive mapping and characterization of salivary pellicles using optical coherence tomography (OCT) and optical coherence microscopy (OCM). The long-term goals are to improve diagnostic capabilities in the oral cavity, gain a better understanding of physiological and pathological processes related to the oral hard tissues, and monitor treatment responses. A salivary pellicle is incubated on small enamel cubes using human whole saliva. OCT and OCM imaging occurs at 0, 10, 30, 60 min, and 24 h. For some imaging, spherical gold nanoparticles (15 nm) are added to determine whether this would increase the optical signal from the pellicle. Multiphoton microscopy (MPM) provides the baseline information. In the saliva-incubated samples, a surface signal from the developing pellicle is visible in OCT images. Pellicle "islands" form, which increase in complexity over time until they merge to form a continuous layer over the enamel surface. Noninvasive, in situ time-based pellicle formation on the enamel surface is visualized and characterized using optical imaging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.