ArticleMolecular and cellular biology1990
Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 77 citations in OpenAlex.
- Phylogenetic evidence for the modular evolution of metazoan signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Earliest Holozoan expansion of phosphotyrosine signaling.Molecular biology and evolution · 2014Article
- Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling.Genome biology · 2013Article
- Evolution of SH2 domains and phosphotyrosine signalling networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Tyrosine phosphorylation-mediated signaling pathways in dictyostelium.Journal of signal transduction · 2011Article
- The dictyostelium kinome--analysis of the protein kinases from a simple model organism.PLoS genetics · 2006Article
- Genome-wide analysis and experimentation of plant serine/ threonine/tyrosine-specific protein kinases.Plant molecular biology · 2006Article
- Characterization of a eukaryotic-like tyrosine protein kinase expressed by the Shiga toxin-encoding bacteriophage 933W.Journal of bacteriology · 2004Article
- Identification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins.BMC genomics · 2003Article
- Developmentally regulated dual-specificity kinase from peanut that is induced by abiotic stresses.Plant physiology · 2002Article
- A receptor tyrosine kinase from choanoflagellates: molecular insights into early animal evolution.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- gdt1, a new signal transduction component for negative regulation of the growth-differentiation transition in Dictyostelium discoideum.Molecular biology of the cell · 2000Article
- The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Phosphotyrosine signaling and the single cell:metazoan boundary.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.Molecular and cellular biology · 1996Article
- Differential accumulation of the transcripts of 22 novel protein kinase genes in Arabidopsis thaliana.Plant molecular biology · 1995Article
- Article
- The Pto bacterial resistance gene and the Fen insecticide sensitivity gene encode functional protein kinases with serine/threonine specificity.Plant physiology · 1995Article
- Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium discoideum, an organism that undergoes development and that is amenable to biochemical and molecular genetic approaches, is an attractive model organism with which to study the role of tyrosine phosphorylation in cell-cell communication. We report the presence of protein-tyrosine kinase genes in D. discoideum. Screening of a Dictyostelium cDNA expression library with an anti-phosphotyrosine antibody identifies fusion proteins that exhibit protein-tyrosine kinase activity. Two distinct cDNAs were identified and isolated. Though highly homologous to protein kinases in general, these kinases do not exhibit many of the hallmarks of protein-tyrosine kinases of higher eucaryotes. In addition, these genes are developmentally regulated, which suggests a role for tyrosine phosphorylation in controlling Dictyostelium development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.