ArticleNeoplasia (New York, N.Y.)2009
Molecular ultrasound imaging of early vascular response in prostate tumors irradiated with carbon ions.
Article in Neoplasia (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Characterization of spatially mapped volumetric molecular ultrasound signals for predicting response to anti-vascular therapy.Scientific reports · 2023Article
- Alternatives for MRI in Prostate Cancer Diagnostics-Review of Current Ultrasound-Based Techniques.Cancers · 2022Review
- Monitoring the Remodeling of Biohybrid Tissue-Engineered Vascular Grafts by Multimodal Molecular Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging.Theranostics · 2018Article
- PBCA-based polymeric microbubbles for molecular imaging and drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Imaging radiation response in tumor and normal tissue.American journal of nuclear medicine and molecular imaging · 2015Review
- Echographic imaging of tumoral cells through novel nanosystems for image diagnosis.World journal of radiology · 2014Review
- Recent advances in molecular, multimodal and theranostic ultrasound imaging.Advanced drug delivery reviews · 2014Review
- Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.Imaging in medicine · 2014Article
- Imaging aspects of the tumor stroma with therapeutic implications.Pharmacology & therapeutics · 2014Review
- Non-invasive imaging for studying anti-angiogenic therapy effects.Thrombosis and haemostasis · 2013Article
- The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-targeted microbubbles (BR55).European radiology · 2013Article
- RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis.Cancers · 2012Article
- Development and validation of an intrinsic landmark-based gating protocol applicable for functional and molecular ultrasound imaging.European radiology · 2012Article
- Ultrasound for molecular imaging and therapy in cancer.Quantitative imaging in medicine and surgery · 2012Article
- Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer.Quantitative imaging in medicine and surgery · 2012Article
- Fluorescently labeled microbubbles for facilitating translational molecular ultrasound studies.Drug delivery and translational research · 2012Article
- Imaging key biomarkers of tumor angiogenesis.Theranostics · 2012Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individualized treatments with combination of radiotherapy and targeted drugs require knowledge about the behavior of molecular targets after irradiation. Angiogenic marker expression has been studied after conventional radiotherapy, but little is known about marker response to charged particles. For the very first time, we used molecular ultrasound imaging to intraindividually track changes in angiogenic marker expression after carbon ion irradiation in experimental tumors. Expression of intercellular adhesion molecule-1 (ICAM-1) and of alpha(v)beta(3)-integrin in subcutaneous AT-1 prostate cancers in rats treated with carbon ions (16 Gy) was studied using molecular ultrasound and immunohistochemistry. For this purpose, cyanoacrylate microbubbles were synthesized and linked to specific ligands. The accumulation of targeted microbubbles in tumors was quantified before and 36 hours after irradiation. In addition, tumor vascularization was analyzed using volumetric Doppler ultrasound. In tumors, the accumulation of targeted microbubbles was significantly higher than in nonspecific ones and could be inhibited competitively. Before irradiation, no difference in binding of alpha(v)beta(3)-integrin-specific or ICAM-1-specific microbubbles was observed in treated and untreated animals. After irradiation, however, treated animals showed a significantly higher binding of alpha(v)beta(3)-integrin-specific microbubbles and an enhanced binding of ICAM-1-specific microbubbles than untreated controls. In both groups, a decrease in vascularization occurred during tumor growth, but no significant difference was observed between irradiated and nonirradiated tumors. In conclusion, carbon ion irradiation upregulates ICAM-1 and alpha(v)beta(3)-integrin expression in tumor neovasculature. Molecular ultrasound can indicate the regulation of these markers and thus may help to identify the optimal drugs and time points in individualized therapy regimens.
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Registered trials
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