ReviewEuropean journal of clinical nutrition2009
Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology.
Review in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01210521 (Use of Vitamin D3 for the Treatment of Steroid Resistant Asthmatic Patients), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Vitamin D3 for the Treatment of Steroid Resistant Asthmatic Patients
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Impact of vitamin D supplementation on post-stroke rehabilitation outcomes: A systematic review and meta-analysis.Narra J · 2025Pooled it
- Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis.Current medicinal chemistry · 2024Pooled it
- Pooled it
- A Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects.Nutrients · 2021Trial
- Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D.The American journal of medicine · 2014Trial
- The osteoporotic niche as a metabolic sanctuary for breast cancer dormancy and reactivation: A mechanistic perspective.iScience · 2026Review
- The Association Between Serum Vitamin D and Lipid Levels in Patients With Depression: A Cross-Sectional Study.Alpha psychiatry · 2026Article
- Emerging perspectives: unraveling the anticancer potential of vitamin DNaunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- The relationships of serum vitamin D concentration with linear speed and change of direction performance in soccer players.Frontiers in nutrition · 2024Article
- 25-Hydroxyvitamin D Levels and Vitamin D3 Supplementation During Postacute Spinal Cord Injury Rehabilitation.Topics in spinal cord injury rehabilitation · 2024Observational
- Editorial: The role of minerals and trace elements in chronic diseases.Frontiers in cell and developmental biology · 2023Article
- The Role of Vitamin D in Stroke Prevention and the Effects of Its Supplementation for Post-Stroke Rehabilitation: A Narrative Review.Nutrients · 2022Review
- Vitamin D supplementation in chronic spinal cord injury (VitD-SCI): study protocol for a randomised controlled trial.BMJ open · 2021Article
- Article
- Ulcerative Colitis-Derived Colonoid Culture: A Multi-Mineral-Approach to Improve Barrier Protein Expression.Frontiers in cell and developmental biology · 2020Article
- Association between vitamin D and hypertension in people coming for health check up to a tertiary care centre in South India.Journal of family medicine and primary care · 2019Article
- Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2019Article
- Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1 alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) and extracellular Ca(2+) act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)(2)D(3)-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.