Evidence map›Paper›PMID 19724260›Full record

ArticleNature cell biology2009

Aurora A moonlights in neurite extension.

Gloria Kuo Lefkowitz, Joseph G Gleeson

Open access · greenAbstract readNewsComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Issues in interpreting the in vivo activity of Aurora-A.Expert opinion on therapeutic targets · 2015
    Review
  4. TPX2: of spindle assembly, DNA damage response, and cancer.Cellular and molecular life sciences : CMLS · 2014
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gloria Kuo Lefkowitz
Joseph G Gleeson
Howard Hughes Medical Institute · US

Funding

Project 3. Genetic Models of Human Structural Brain Defects in ZebrafishP01HD070494 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2011 to 2016
$6.7M
Molecular Characterization of Joubert SyndromeR01NS048453 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2004 to 2020
$6.0M
NICHD NIH HHS P01 HD070494NINDS NIH HHS R01 NS048453
6 · The paper itself

Abstract

Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.

Indexed as

AnimalsAurora Kinase AAurora KinasesCarrier ProteinsMiceMicrotubulesModels, BiologicalNeuritesPhosphothreonineProtein Kinase CProtein Serine-Threonine KinasesSignal TransductionAurka protein, mouseAurora Kinase AAurora KinasesCarrier ProteinsNdel1 protein, mousePhosphothreoninePKC-3 proteinProtein Kinase CProtein Serine-Threonine Kinases

Identifiers

PMID19724260
PMCPMC4902652
OpenAlexW2055839028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.