ArticleThe Journal of endocrinology2009
Development of the human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence.
Article in The Journal of endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
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- Adrenal AKR1C3-mediated androgen activation contributes to hyperandrogenism in prepubertal ovariectomized rats.Translational pediatrics · 2026Article
- Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes.European journal of endocrinology · 2024Article
- Local Effects of Steroid Hormones within the Bone Microenvironment.International journal of molecular sciences · 2023Review
- Normal and Premature Adrenarche.Endocrine reviews · 2021Review
- Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia.Frontiers in endocrinology · 2021Article
- 11-Oxygenated androgens in health and disease.Nature reviews. Endocrinology · 2020Review
- Lasting Impact of Chronic Adolescent Stress and Glucocorticoid Receptor Selective Modulation in Male and Female Rats.Psychoneuroendocrinology · 2020Article
- Steroid biomarkers in human adrenal disease.The Journal of steroid biochemistry and molecular biology · 2019Review
- 11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche.The Journal of clinical endocrinology and metabolism · 2018Observational
- Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: A post-mortem study.Brain pathology (Zurich, Switzerland) · 2018Article
- New insights into morphological, stereological and functional studies of the adrenal gland under exposure to the potent goitrogen thiourea.Interdisciplinary toxicology · 2018Article
- Genetic and environmental influences on pubertal hormones in human hair across development.Psychoneuroendocrinology · 2018Article
- TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors.Frontiers in endocrinology · 2018Article
- The Rise, Fall, and Resurrection of 11-Oxygenated Androgens in Human Physiology and Disease.Hormone research in paediatrics · 2018Review
- Identification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline TP53 Mutations: A St Jude Adrenocortical Tumor Registry and Children's Oncology Group Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate.The Journal of clinical endocrinology and metabolism · 2016Article
- The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.The Journal of steroid biochemistry and molecular biology · 2016Review
- 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging.Endocrine research · 2015Article
- Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.Comprehensive Physiology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Age-related morphologic development of human adrenal zona reticularis (ZR) has not been well examined. Therefore, in this study, 44 human young adrenal autopsy specimens retrieved from large archival files (n=252) were examined for immunohistochemical and morphometric analyses. Results demonstrated that ZR became discernible around 4 years of age, and both thickness and ratio per total cortex of ZR increased in an age-dependent fashion thereafter, although there was no significant increment in total thickness of developing adrenal cortex. We further evaluated immunoreactivity of both KI67 and BCL2 in order to clarify the equilibrium between cell proliferation and apoptosis in the homeostasis of developing human adrenals. Results demonstrated that proliferative adrenocortical cells were predominantly detected in the zona glomerulosa and partly in outer zona fasciculata (ZF) before 4 years of age and in ZR after 4 years of age, but the number of these cells markedly decreased around 20 years of age. The number of BCL2-positive cells increased in ZR and decreased in ZF during development. Adrenal androgen synthesizing type 5 17beta-hydroxysteroid dehydrogenase (HSD17B5 or AKR1C3 as listed in the Hugo Database) was almost confined to ZR of human adrenals throughout development. HSD17B5 immunoreactivity in ZR became discernible and increased from around 9 years of age. Results of our present study support the theory of age-dependent adrenocortical cell migration and also indicated that ZR development is not only associated with adrenarche, but may play important roles in an initiation of puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.