ArticleJournal of cell science2009
The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
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- Molecular Fingerprint of BMD Patients Lacking a Portion in the Rod Domain of Dystrophin.International journal of molecular sciences · 2022Article
- Epigenetic regulation of satellite cell fate during skeletal muscle regeneration.Skeletal muscle · 2021Review
- Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.BMC genomics · 2018Article
- The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation.Cell reports · 2018Article
- High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer.Cancer management and research · 2018Article
- Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.Scientific reports · 2017Article
- Mimicking Muscle Stem Cell Quiescence in Culture: Methods for Synchronization in Reversible Arrest.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway.Frontiers in cell and developmental biology · 2016Review
- Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover.Physiological genomics · 2015Article
- Expression of p8 in Human Oral Squamous Cell Carcinoma.Head and neck pathology · 2015Article
- P68 RNA helicase as a molecular target for cancer therapy.Journal of experimental & clinical cancer research : CR · 2014Review
- The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species.Genes & cancer · 2014Article
- Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank.Breast cancer research : BCR · 2014Article
- Distinct transcriptional networks in quiescent myoblasts: a role for Wnt signaling in reversible vs. irreversible arrest.PloS one · 2014Article
- Nupr1 deletion protects against glucose intolerance by increasing beta cell mass.Diabetologia · 2013Article
- Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.EMBO molecular medicine · 2012Article
- The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation.Cell death and differentiation · 2012Article
- Expression and roles of NUPR1 in cholangiocarcinoma cells.Anatomy & cell biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Quiescent muscle progenitors called satellite cells persist in adult skeletal muscle and, upon injury to muscle, re-enter the cell cycle and either undergo self-renewal or differentiate to regenerate lost myofibers. Using synchronized cultures of C2C12 myoblasts to model these divergent programs, we show that p8 (also known as Nupr1), a G1-induced gene, negatively regulates the cell cycle and promotes myogenic differentiation. p8 is a small chromatin protein related to the high mobility group (HMG) family of architectural factors and binds to histone acetyltransferase p300 (p300, also known as CBP). We confirm this interaction and show that p300-dependent events (Myc expression, global histone acetylation and post-translational acetylation of the myogenic regulator MyoD) are all affected in p8-knockdown myoblasts, correlating with repression of MyoD target-gene expression and severely defective differentiation. We report two new partners for p8 that support a role in muscle-specific gene regulation: p68 (Ddx5), an RNA helicase reported to bind both p300 and MyoD, and MyoD itself. We show that, similar to MyoD and p300, p8 and p68 are located at the myogenin promoter, and that knockdown of p8 compromises chromatin association of all four proteins. Thus, p8 represents a new node in a chromatin regulatory network that coordinates myogenic differentiation with cell-cycle exit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.