ArticleThe Journal of biological chemistry2009
SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Integrating AlphaFold2, RoseTTAFold2, and HADDOCK to refine Protein-Protein Interaction (PPI) candidate selection: A case study with ZWINT.Biochemistry and biophysics reports · 2026Article
- Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia.BMC veterinary research · 2025Article
- Unlocking New Therapeutic Options for Vincristine-Induced Neuropathic Pain: The Impact of Preclinical Research.Life (Basel, Switzerland) · 2024Review
- How inflammation dictates diabetic peripheral neuropathy: An enlightening review.CNS neuroscience & therapeutics · 2024Review
- Phylogenetic analysis of mammalian SIP30 sequences indicating accelerated adaptation of functional domain in primates.Biochemistry and biophysics reports · 2024Article
- SIP30 involvement in vesicle exocytosis from PC12 cells.Biochemistry and biophysics reports · 2024Article
- Review
- Analysis of pain markers and epidural fibrosis caused by repeated spinal surgery in Sprague-Dawley rats.BMC musculoskeletal disorders · 2021Article
- Genomic inbreeding trends, influential sire lines and selection in the global Thoroughbred horse population.Scientific reports · 2020Article
- A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.BMC genetics · 2018Article
- Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation.American journal of cancer research · 2018Article
- Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons.Redox biology · 2016Article
- Lithium promotes DNA stability and survival of ischemic retinal neurocytes by upregulating DNA ligase IV.Cell death & disease · 2016Article
- SNAP25 ameliorates sensory deficit in rats with spinal cord transection.Molecular neurobiology · 2014Article
- Article
- SIP30 is required for neuropathic pain-evoked aversion in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning.Cell research · 2012Article
- Estrogen facilitates spinal cord synaptic transmission via membrane-bound estrogen receptors: implications for pain hypersensitivity.The Journal of biological chemistry · 2012Article
- Cancer-induced bone pain sequentially activates the ERK/MAPK pathway in different cell types in the rat spinal cord.Molecular pain · 2011Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter. Taken together, our results provide a potential downstream target of ERK activation-mediated neuropathic pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.