ArticleRespiratory research2009
Expression profiling identifies genes involved in emphysema severity.
Article in Respiratory research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.Scientific reports · 2017Trial
- Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.American journal of respiratory cell and molecular biology · 2013Trial
- Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study.International journal of molecular sciences · 2026Article
- NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma.Cell communication and signaling : CCS · 2024Article
- SNPs Sets in Codifying Genes for Xenobiotics-Processing Enzymes Are Associated with COPD Secondary to Biomass-Burning Smoke.Current issues in molecular biology · 2023Article
- Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment.International journal of molecular sciences · 2019Article
- The neurotrophin Neuritin1 (cpg15) is involved in melanoma migration, attachment independent growth, and vascular mimicry.Oncotarget · 2017Article
- An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica - Fritillaria usuriensis dropping pills for pulmonary diseases.BMC complementary and alternative medicine · 2016Article
- Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects.International journal of genomics · 2015Article
- Biomarkers of progression of chronic obstructive pulmonary disease (COPD).Journal of thoracic disease · 2014Review
- Integrative genomics of chronic obstructive pulmonary disease.Biochemical and biophysical research communications · 2014Review
- MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression.BMC genomics · 2014Article
- Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- miR-638 regulates gene expression networks associated with emphysematous lung destruction.Genome medicine · 2013Article
- Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case-control study.BMJ open · 2012Article
- A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.Genome medicine · 2012Article
- Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.Proceedings of the American Thoracic Society · 2011Article
- Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD.PloS one · 2011Article
- Identification of novel candidate genes involved in the progression of emphysema by bioinformatic methods.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease (COPD) is a major public health problem. The aim of this study was to identify genes involved in emphysema severity in COPD patients.Gene expression profiling was performed on total RNA extracted from non-tumor lung tissue from 30 smokers with emphysema. Class comparison analysis based on gas transfer measurement was performed to identify differentially expressed genes. Genes were then selected for technical validation by quantitative reverse transcriptase-PCR (qRT-PCR) if also represented on microarray platforms used in previously published emphysema studies. Genes technically validated advanced to tests of biological replication by qRT-PCR using an independent test set of 62 lung samples.Class comparison identified 98 differentially expressed genes (p < 0.01). Fifty-one of those genes had been previously evaluated in differentiation between normal and severe emphysema lung. qRT-PCR confirmed the direction of change in expression in 29 of the 51 genes and 11 of those validated, remaining significant at p < 0.05. Biological replication in an independent cohort confirmed the altered expression of eight genes, with seven genes differentially expressed by greater than 1.3 fold, identifying these as candidate determinants of emphysema severity.Gene expression profiling of lung from emphysema patients identified seven candidate genes associated with emphysema severity including COL6A3, SERPINF1, ZNHIT6, NEDD4, CDKN2A, NRN1 and GSTM3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.