ArticleArthritis research & therapy2009
Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice.
Article in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Immunometabolism in rheumatoid arthritis: mechanisms, biomarkers, and the path to precision medicine.Frontiers in immunology · 2026Review
- The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity.Molecules (Basel, Switzerland) · 2024Review
- Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification.Inflammopharmacology · 2024Article
- The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle.Frontiers in veterinary science · 2024Review
- Sodium dichloroacetate improves migration ability by suppressing LPS-induced inflammation in HTR-8/SVneo cells via the TLR4/NF-κB pathway.Iranian journal of basic medical sciences · 2024Article
- The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis.Arthritis research & therapy · 2023Review
- Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.Cardiovascular research · 2023Article
- The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation.Molecules and cells · 2023Review
- Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming.Scientific reports · 2023Article
- Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases.Journal of diabetes investigation · 2021Review
- Pyruvate dehydrogenase kinase/lactate axis: a therapeutic target for neovascular age-related macular degeneration identified by metabolomics.Journal of molecular medicine (Berlin, Germany) · 2020Article
- The Role of Metabolic Enzymes in the Regulation of Inflammation.Metabolites · 2020Review
- The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages.Journal of molecular cell biology · 2020Article
- Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4Cell metabolism · 2020Article
- Targeting metabolism to regulate immune responses in autoimmunity and cancer.Nature reviews. Drug discovery · 2019Review
- Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.Biomedical reports · 2017Article
- Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.Cell metabolism · 2017Article
- Fine tuning of immunometabolism for the treatment of rheumatic diseases.Nature reviews. Rheumatology · 2017Review
- Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.Arthritis research & therapy · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDichloroacetate (DCA) has been in clinical use for the treatment of lactacidosis and inherited mitochondrial disorders. It has potent anti-tumor effects both in vivo and in vitro, facilitating apoptosis and inhibiting proliferation. The pro-apoptotic and anti-proliferative properties of DCA prompted us to investigate the effects of this compound in arthritis.
methodsIn the present study, we used DCA to treat murine collagen type II (CII)-induced arthritis (CIA), an experimental model of rheumatoid arthritis. DBA/1 mice were treated with DCA given in drinking water.
resultsMice treated with DCA displayed much slower onset of CIA and significantly lower severity (P < 0.0001) and much lower frequency (36% in DCA group vs. 86% in control group) of arthritis. Also, cartilage and joint destruction was significantly decreased following DCA treatment (P = 0.005). Moreover, DCA prevented arthritis-induced cortical bone mineral loss. This clinical picture was also reflected by lower levels of anti-CII antibodies in DCA-treated versus control mice, indicating that DCA affected the humoral response. In contrast, DCA had no effect on T cell- or granulocyte-mediated responses. The beneficial effect of DCA was present in female DBA/1 mice only. This was due in part to the effect of estrogen, since ovariectomized mice did not benefit from DCA treatment to the same extent as sham-operated controls (day 30, 38.7% of ovarectomized mice had arthritis vs. only 3.4% in sham-operated group).
conclusionOur results indicate that DCA delays the onset and alleviates the progression of CIA in an estrogen-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.