Evidence map›Paper›PMID 19722558›Full record

ArticleBiomacromolecules2009

Virus-inspired approach to nonviral gene delivery vehicles.

Raghunath Roy, D Joseph Jerry, S Thayumanavan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Charge-Conversion Strategies for Nucleic Acid Delivery.Advanced functional materials · 2021
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raghunath RoyDepartment of Chemistry and Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA.
D Joseph Jerry
S Thayumanavan
University of Massachusetts Amherst · US

Funding

Hormonal regulation of p53 activity in mammary tissueR01CA095164 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH · 2004 to 2008
$1.5M
Genetic modifiers of mammary tumor susceptibilityR01CA105452 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH · 2005 to 2009
$1.5M
NCI NIH HHS R01 CA095164NCI NIH HHS R01 CA105452
6 · The paper itself

Abstract

The basic TAT peptide, responsible for translocation of the HIV-TAT protein, has been conjugated to a variety of artificial nanoscopic materials to transport them across the cellular membrane. However, attempts to translocate genes using the TAT-peptide had met with limited success. We hypothesized that the cationic nature of the peptide does not allow for displaying these peptides on the surface of the polyplex. To circumvent this potential issue, we have developed a new molecular design strategy where the TAT-peptide can be effectively displayed on the surface of the polyplex, thus enhancing gene expression.

Indexed as

Gene Products, tatGene Transfer TechniquesBreast NeoplasmsCells, CulturedFemaleGenetic VectorsHumansKidneyPeptide FragmentsPolymersTransfectionGene Products, tatPeptide FragmentsPolymers

Identifiers

PMID19722558
PMCPMC4629854
OpenAlexW2066059106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.