ArticleBiomacromolecules2009
Silk-elastinlike protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors.
Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Protein-based nanoparticles for therapeutic nucleic acid delivery.Biomaterials · 2024Review
- Review
- Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing.International journal of molecular sciences · 2022Review
- Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials.Nanomaterials (Basel, Switzerland) · 2021Review
- The pharmacology of plant virus nanoparticles.Virology · 2021Review
- Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly.Nature communications · 2020Article
- Review
- Protein-Engineered Functional Materials.Advanced healthcare materials · 2019Review
- Controlled release from recombinant polymers.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Silk-based biomaterials for sustained drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Local sustained delivery of oncolytic adenovirus with injectable alginate gel for cancer virotherapy.Gene therapy · 2013Article
- Photoresponsive retinal-modified silk-elastin copolymer.Journal of the American Chemical Society · 2013Article
- Smart self-assembled hybrid hydrogel biomaterials.Angewandte Chemie (International ed. in English) · 2012Review
- Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery.International journal of pharmaceutics · 2012Article
- Elastomeric polypeptides.Topics in current chemistry · 2012Review
- Design properties of hydrogel tissue-engineering scaffolds.Expert review of medical devices · 2011Review
- Engineering biomaterial systems to enhance viral vector gene delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Review
- Applications of elastin-like polypeptides in tissue engineering.Advanced drug delivery reviews · 2010Review
- Silk-based delivery systems of bioactive molecules.Advanced drug delivery reviews · 2010Review
- Gene delivery mediated by recombinant silk proteins containing cationic and cell binding motifs.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Vector dissemination, transient gene expression, and rapid clearance are major obstacles to successful human gene therapy. In this study, we investigated the effect of silk-elastinlike protein polymer (SELP) hydrogels on biodistribution and anticancer efficacy of adenoviral gene therapy in a head and neck cancer model. Transcriptional activities of adenovirus carrying beta-galactosidase (Ad-LacZ) and luciferase (Ad-Luc) reporter genes were evaluated in (nu/nu) mice with head and neck cancer as a function of polymer concentration. Antitumor efficacy of thymidine kinase encoding adenovirus (Ad-Tk) and ganciclovir (GSV) combination was also evaluated. SELP (4 wt %) matrices localized viral release, minimized dissemination to liver, and enhanced reporter gene expression levels by 4-8-fold compared to virus alone. SELP- Ad-Tk with GSV reduced tumor volume significantly compared to the virus alone. SELPs provide a means for temporal and spatial control of viral gene delivery to head and neck tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.