ArticleThe Journal of experimental medicine1990
Spontaneous loss and alteration of antigen receptor expression in mature CD4+ T cells.
Article in The Journal of experimental medicine, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 89 citations in OpenAlex.
- Association study of xenobiotic detoxication and repair genes with malignant brain tumors in children.Acta naturae · 2010Article
- Interindividual variation in mitotic recombination.American journal of human genetics · 1999Article
- Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome.Clinical and experimental immunology · 1998Article
- Monitoring exposure to atomic bomb radiation by somatic mutation.Environmental health perspectives · 1996Article
- Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.Japanese journal of cancer research : Gann · 1994Article
- Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.Environmental health perspectives · 1993Article
- Flow cytometric measurements of somatic cell mutations in Thorotrast patients.Japanese journal of cancer research : Gann · 1991Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TCR/CD3 complex plays a central role in antigen recognition and activation of mature T cells, and, therefore, abnormalities in the expression of the complex should induce unresponsiveness of T cells to antigen stimulus. Using flow cytometry, we detected and enumerated variant cells with loss or alteration of the surface TCR/CD3 expression among human mature CD4+ T cells. The presence of variant CD4+ T cells was demonstrated by isolating and cloning them from peripheral blood, and their abnormalities can be accounted for by alterations in TCR expression such as defects of protein expression and partial protein deletion. The variant frequency in peripheral blood increased with aging in normal donors and was highly elevated in patients with ataxia telangiectasia, an autosomal recessive inherited disease with defective DNA repair and variable T cell immunodeficiency. These findings suggest that such alterations in TCR expression are induced by somatic mutagenesis of TCR genes and can be important factors related to age-dependent and genetic disease-associated T cell dysfunction.
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