ArticleInternational journal of obesity (2005)2009
Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci.
Article in International journal of obesity (2005), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Association between LGR4 polymorphisms and peak bone mineral density and body composition.Journal of bone and mineral metabolism · 2020Article
- Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China.Bioscience reports · 2019Article
- Mendelian Inconsistent Signatures from 1314 Ancestrally Diverse Family Trios Distinguish Biological Variation from Sequencing Error.Journal of computational biology : a journal of computational molecular cell biology · 2019Article
- A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila.Cell metabolism · 2019Article
- Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.The Journal of rheumatology · 2017Article
- An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing.Medicine · 2017Observational
- A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.Journal of obesity · 2015Article
- Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.Nature cell biology · 2013Article
- The Danish Twin Registry: linking surveys, national registers, and biological information.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
- Cohort Profile: TwinsUK and healthy ageing twin study.International journal of epidemiology · 2013Article
- Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis.Kidney international · 2011Article
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Authors and funding
25 authors at 12 institutions in 8 countries.
Funding
Abstract
objectiveTo identify common loci and potential genetic variants affecting body mass index (BMI, kg m(-2)) in study populations originating from Europe.
designWe combined genome-wide linkage scans of six cohorts from Australia, Denmark, Finland, the Netherlands, Sweden and the United Kingdom with an approximately 10-cM microsatellite marker map. Variance components linkage analysis was carried out with age, sex and country of origin as covariates. SUBJECTS: The GenomEUtwin consortium consists of twin cohorts from eight countries (Australia, Denmark, the Netherlands, Finland, Italy, Norway, Sweden and the United Kingdom) with a total data collection of more than 500,000 monozygotic and dizygotic (DZ) twin pairs. Variance due to early-life events and the environment is reduced within twin pairs, which makes DZ pairs highly valuable for linkage studies of complex traits. This study totaled 4401 European-originated twin families (10,535 individuals) from six countries (Australia, Denmark, the Netherlands, Finland, Sweden and the United Kingdom).
resultsWe found suggestive evidence for a quantitative trait locus on 3q29 and 7q36 in the combined sample of DZ twins (multipoint logarithm of odds score (MLOD) 2.6 and 2.4, respectively). Two individual cohorts showed strong evidence independently for three additional loci: 16q23 (MLOD=3.7) and 2p24 (MLOD=3.4) in the Dutch cohort and 20q13 (MLOD=3.2) in the Finnish cohort.
conclusionLinkage analysis of the combined data in this large twin cohort study provided evidence for suggestive linkage to BMI. In addition, two cohorts independently provided significant evidence of linkage to three new loci. The results of our study suggest a smaller environmental variance between DZ twins than full siblings, with a corresponding increase in heritability for BMI as well as an increase in linkage signal in well-replicated regions. The results are consistent with the possibility of locus heterogeneity for some genomic regions, and indicate a lack of major common quantitative trait locus variants affecting BMI in European populations.
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