ArticleGenetics2009
A combined-cross analysis reveals genes with drug-specific and background-dependent effects on drug sensitivity in Saccharomyces cerevisiae.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth.The Journal of cell biology · 2025Article
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- High-throughput approaches to functional characterization of genetic variation in yeast.Current opinion in genetics & development · 2022Review
- CRISPR/Cas9-mediated point mutations improve α-amylase secretion in Saccharomyces cerevisiae.FEMS yeast research · 2022Article
- Article
- Model selection emphasises the importance of non-chromosomal information in genetic studies.PloS one · 2015Article
- Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains.Genetics · 2014Article
- Interactions between chromosomal and nonchromosomal elements reveal missing heritability.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae.Genetics · 2014Article
- The molecular basis of phenotypic variation in yeast.Current opinion in genetics & development · 2013Review
- Rare variants in hypermutable genes underlie common morphology and growth traits in wild Saccharomyces paradoxus.Genetics · 2013Article
- Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis.Genome research · 2012Article
- Genetic architecture of highly complex chemical resistance traits across four yeast strains.PLoS genetics · 2012Article
- Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiae.Eukaryotic cell · 2011Article
- Dissection of genetically complex traits with extremely large pools of yeast segregants.Nature · 2010Article
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Authors and funding
2 authors.
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Abstract
Effective pharmacological therapy is often inhibited by variable drug responses and adverse drug reactions. Dissecting the molecular basis of different drug responses is difficult due to complex interactions involving multiple genes, pathways, and cellular processes. We previously found a single nucleotide polymorphism within cystathionine beta-synthase (CYS4) that causes multi-drug sensitivity in a vineyard strain of Saccharomyces cerevisiae. However, not all variation was accounted for by CYS4. To identify additional genes influencing drug sensitivity, we used CYS4 as a covariate and conducted both single- and combined-cross linkage mapping. After eliminating numerous false-positive associations, we identified 16 drug-sensitivity loci, only 3 of which had been previously identified. Of 4 drug-sensitivity loci selected for validation, 2 showed replicated associations in independent crosses, and two quantitative trait genes within these regions, AQY1 and MKT1, were found to have drug-specific and background-dependent effects. Our results suggest that drug response may often depend on interactions between genes with multi-drug and drug-specific effects.
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