ReviewMayo Clinic proceedings2009
Sympathetic neural mechanisms in human cardiovascular health and disease.
Review in Mayo Clinic proceedings, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.
- Exercise training to reduce sympathetic nerve activity in heart failure patients. A systematic review and meta-analysis.Brazilian journal of physical therapyPooled it
- Trial
- Association between multiple sleep dimensions in obstructive sleep apnea and an early sign of atherosclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Inspiratory muscle strength training lowers blood pressure and sympathetic activity in older adults with OSA: a randomized controlled pilot trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- A comparison of the effect of a variety of thermal and vibratory modalities on skin temperature and blood flow in healthy volunteers.Medical science monitor : international medical journal of experimental and clinical research · 2011Trial
- Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues.The Journal of endocrinology · 2026Review
- Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF.NeuroImage · 2026Article
- Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post-traumatic stress disorder.Experimental physiology · 2026Article
- Wearable-derived skin temperature dynamics during sleep reveal cardiovascular perfusion deficits through mechanistic modeling.NPJ digital medicine · 2026Article
- A multidimensional examination of pain threshold and non-suicidal self-injury: psychological and physiological determinants in adolescents.BJPsych open · 2026Article
- The Heart-Brain Axis in the Context of Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- Correlation between ambulatory blood pressure indices and sex hormone imbalance in hypertensive women with different menopausal durations: a cross-sectional study.European journal of medical research · 2026Observational
- Effects of Multicomponent and Multiprofessional Interventions on Cardiovascular and Functional Health in Hypertensive and Normotensive Older Women: A Case Study.Journal of clinical medicine · 2026Article
- Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Protocol Using a Mixed Modeling Approach.Psychophysiology · 2026Article
- Effect of unmanned aerial vehicle mission difficulty level on pilot's autonomic nervous system.International journal of occupational medicine and environmental health · 2025Article
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- The effect of uninterrupted and interrupted sitting on vascular function in adults with long COVID.Physiological reports · 2025Article
- The neuronal imaging in cardiology: 123I-Biophysical reviews · 2025Review
- Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic nervous system plays a key role in regulating arterial blood pressure in humans. This review provides an overview of sympathetic neural control of the circulation and discusses the changes that occur in various disease states, including hypertension, heart failure, and obstructive sleep apnea. It focuses on measurements of sympathetic neural activity (SNA) obtained by microneurography, a technique that allows direct assessment of the electrical activity of sympathetic nerves in conscious human beings. Sympathetic neural activity is tightly linked to blood pressure via the baroreflex for each individual person. However, SNA can vary greatly among individuals and that variability is not related to resting blood pressure; that is, the blood pressure of a person with high SNA can be similar to that of a person with much lower SNA. In healthy normotensive persons, this finding appears to be related to a set of factors that balance the variability in SNA, including cardiac output and vascular adrenergic responsiveness. Measurements of SNA are very reproducible in a given person over a period of several months to a few years, but SNA increases progressively with healthy aging. Cardiovascular disease can be associated with substantial increases in SNA, as seen for example in patients with hypertension, obstructive sleep apnea, or heart failure. Obesity is also associated with an increase in SNA, but the increase in SNA among patients with obstructive sleep apnea appears to be independent of obesity per se. For several disease states, successful treatment is associated with both a decrease in sympathoexcitation and an improvement in prognosis. This finding points to an important link between altered sympathetic neural mechanisms and the fundamental processes of cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.