ArticleMayo Clinic proceedings2009
The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus.
Article in Mayo Clinic proceedings, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Exercise on Cardiometabolic Risk Factors in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Rosiglitazone improves insulin resistance but does not improve exercise capacity in individuals with impaired glucose tolerance: A randomized clinical study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2024Trial
- Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men-a randomized controlled trial.Endocrine · 2018Trial
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- Trial
- Relation of vitamin D level to maximal oxygen uptake in adults.The American journal of cardiology · 2011Trial
- The joint association of obesity and physical activity on cognitive function in Down syndrome.Journal of Alzheimer's disease : JAD · 2025Article
- Physical Exercise on Aerobic Capacity in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.American journal of lifestyle medicine · 2025Review
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- A narrative review of exercise participation among adults with prediabetes or type 2 diabetes: barriers and solutions.Frontiers in clinical diabetes and healthcare · 2023Review
- Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes.European journal of applied physiology · 2022Article
- The Effects of Exercise on Lipid Biomarkers.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Barriers in translating preclinical rodent exercise metabolism findings to human health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Aerobic capacity is associated with disease activity and cardiovascular risk factors in early rheumatoid arthritis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2020Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Relationship of Cardiorespiratory Fitness and Body Mass Index with the Incidence of Dyslipidemia among Japanese Women: A Cohort Study.International journal of environmental research and public health · 2019Article
- Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus.Preventive medicine reports · 2017Article
- Long Term Home-Based Exercise is Effective to Reduce Blood Pressure in Low Income Brazilian Hypertensive Patients: A Controlled Trial.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Article
- Association of body mass index with all-cause mortality in patients with diabetes: a systemic review and meta-analysis.Cardiovascular diagnosis and therapy · 2016Article
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6 authors.
Funding
Abstract
objectiveTo evaluate the independent and joint associations among cardiorespiratory fitness (CRF), body mass index, and risk of mortality from any cause among women with impaired fasting glucose (IFG) or undiagnosed diabetes mellitus (DM). PATIENTS AND
methodsFemale patients (N=3044; mean age, 47.4 years) with IFG or undiagnosed DM completed a maximal exercise treadmill test (between January 26, 1971, and March 21, 2001). The women had no history of a cardiovascular disease event or diagnosed DM at baseline. Cardiorespiratory fitness was defined categorically as low (bottom 20%), moderate (middle 40%), or high (upper 40%) according to previously published Aerobics Center Longitudinal Study guidelines. Body mass index was calculated as the weight in kilograms divided by the height in meters squared (kg/m(2)).
resultsDuring a 16-year follow-up period, 171 deaths occurred. There was an inverse association between CRF and all-cause mortality risk. Women with moderate or high CRF were at lower risk of mortality (moderate CRF, 35% lower; high CRF, 36% lower; P(trend)=.03) than those with low CRF. An exercise capacity lower than 7 metabolic equivalents was associated with a 1.5-fold higher risk of death than an exercise capacity of 9 metabolic equivalents or higher (P(trend)=.05). The multivariate adjusted hazard ratios (HRs), including adjustments for CRF, were higher for heavier patients than for patients of normal weight (overweight patients: HR, 0.86; 95% confidence interval, 0.57-1.30; obese patients: HR, 1.19; 95% confidence interval, 0.70-2.03; P(trend)=.84). Combined analyses showed that women who were overweight or obese and unfit (low CRF) were at more than twice the risk of death than women who were of normal weight and fit (moderate or high CRF).
conclusionCardiorespiratory fitness, not body mass index, is a significant predictor of all-cause mortality among women with IFG or undiagnosed DM. Assessing CRF levels provides important prognostic information independent of traditional risk factors.
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