ArticleCardiovascular research2010
Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10.
Article in Cardiovascular research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Atherosclerosis antigens as targets for immunotherapy.Nature cardiovascular research · 2023Review
- Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.International journal of medical sciences · 2020Observational
- Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis inFrontiers in physiology · 2020Article
- The role of B cells in atherosclerosis.Nature reviews. Cardiology · 2019Review
- Readapting the adaptive immune response - therapeutic strategies for atherosclerosis.British journal of pharmacology · 2017Review
- Fcγ Receptors in Solid Organ Transplantation.Current transplantation reports · 2016Review
- Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice.Annals of the rheumatic diseases · 2015Article
- Fcγ receptors and ligands and cardiovascular disease.Circulation research · 2015Review
- Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques.Journal of the American Heart Association · 2014Article
- Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- B cells and humoral immunity in atherosclerosis.Circulation research · 2014Review
- The influence of innate and adaptive immune responses on atherosclerosis.Annual review of pathology · 2014Review
- Gene Deficiency in Activating Fcγ Receptors Influences the Macrophage Phenotypic Balance and Reduces Atherosclerosis in Mice.PloS one · 2013Article
- Adaptive immunity in atherogenesis: new insights and therapeutic approaches.The Journal of clinical investigation · 2013Review
- Potential cardiovascular disease risk markers among HIV-infected women initiating antiretroviral treatment.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway.The American journal of pathology · 2012Article
- Model IgG monoclonal autoantibody-anti-idiotype pair for dissecting the humoral immune response to oxidized low density lipoprotein.Hybridoma (2005) · 2012Article
- Genetic basis of atherosclerosis: insights from mice and humans.Circulation research · 2012Review
- B cell subsets in atherosclerosis.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsGiven the importance of IgG Fc receptors in immune regulation, we hypothesized that Fcg receptor type III (FcgRIII, CD16) plays an important role in atherogenesis. We therefore analysed the formation of arterial lesions in LDL receptor-deficient (LDLR(-/-)) and FcgRIII(-/-)xLDLR(-/-) double knockout mice at three different points up to 24 weeks of exposure to a high-fat diet. METHODS AND
resultsAnalysis of Oil Red-O-stained sections revealed no difference in lesion formation between strains after 6 weeks of a high-fat diet, and a modest decrease after 14 weeks in double knockouts relative to LDLR(-/-) controls. After 24 weeks, lesion formation was decreased in the aortic root (30%) and innominate artery (50%) in FcgRIII double knockouts relative to LDLR(-/-) controls. Analysis of peripheral CD4+ T-cells by intracellular flow cytometry from double knockouts after 24 weeks of a high-fat diet revealed statistically significant increases in the percentages of cells producing interferon-gamma, interleukin (IL)-10, and IL-4 relative to controls, differences that were also observed by analyses of whole aortas for cytokine mRNA levels. As determined by flow cytometry, FcgRIII deficiency resulted in an expansion of CD4+ cells and an increase in the CD4 to CD8 ratio. Analysis of plasma anti-oxidized LDL (OxLDL) antibodies by chemiluminescent assay revealed that IgG1 and IgG2c titers to OxLDL were increased in FcgRIII (-/-)xLDLR(-/-) double knockouts relative to LDLR(-/-) controls, while total IgG levels were similar.
conclusionThese results reveal altered immunity in FcgRIII(-/-)xLDLR(-/-) mice and a reduction in lesion formation associated with increased production of IL-10 by an expansion of CD4+ T-cells. The reduction in lesion formation was manifest well after evidence of an immune response to OxLDL, suggesting that FcgRIII contributes to lesion progression in murine atherosclerosis.
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Registered trials
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