ArticleJournal of endodontics2009
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
Article in Journal of endodontics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- The effect of calcium hydroxide and double antibiotic paste on radiographic outcomes and periapical MMP-8 levels in regenerative endodontic procedures: a randomized clinical trial.Journal of applied oral science : revista FOB · 2024Trial
- Cross-Sectional Analysis of Matrix Metalloproteinases and Bone Resorption Regulators in Apical Periodontitis: Linking Molecular Mechanisms with Clinical and Histopathological Features.Acta stomatologica Croatica · 2025Article
- ScRNA-Seq Analysis of Tongue Tissues in Chronic Hyperplastic Candidiasis.Journal of dental research · 2025Article
- In Situ Zymography in Formalin-Fixed Paraffin-Embedded and Mineralized Tissues.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.European endodontic journal · 2023Review
- Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Clinical influence of calcium hydroxide intracanal medications on matrix metalloproteinases and tissue inhibitors of metalloproteinases in apical periodontitis.Clinical oral investigations · 2022Article
- Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.BMC oral health · 2021Article
- Role of matrix metalloproteinases and their tissue inhibitors in the pathological mechanisms underlying maxillofacial cystic lesions.Biomedical reports · 2021Article
- Osteoclast formation, inflammation, and matrix metalloproteinase-9 are downregulated in bone repair following root canal treatment in dogs teeth.Clinical oral investigations · 2021Article
- The NFκB Expression on Apical Dental Granuloma: An Immunohistochemistry Analysis.Clinical, cosmetic and investigational dentistry · 2020Article
- Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage.Journal of applied oral science : revista FOB · 2019Article
- Removal of Pre-Existing Periodontal Inflammatory Condition before Tooth Extraction Ameliorates Medication-Related Osteonecrosis of the Jaw-Like Lesion in Mice.The American journal of pathology · 2018Article
- Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.Progress in polymer science · 2017Review
- Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction-induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice.Journal of endodontics · 2016Article
- Genome-wide approaches (GWA) in oral and craniofacial diseases research.Oral diseases · 2013Review
- Heparanase expression in periapical granulomas and radicular cysts.Odontology · 2013Article
- Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.Journal of endodontics · 2012Article
- Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response.Journal of inflammation (London, England) · 2012Article
- Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.Journal of endodontics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionThe inability to distinguish periapical cysts from granulomas before performing root canal treatment leads to uncertainty in treatment outcomes because cysts have lower healing rates. Searching for differential expression of molecules within cysts or granulomas could provide information with regard to the identity of the lesion or suggest mechanistic differences that may form the basis for future therapeutic intervention. Thus, we investigated whether granulomas and cysts exhibit differential expression of extracellular matrix (ECM) molecules.
methodsHuman periapical granulomas, periapical cysts, and healthy periodontal ligament tissues were used to investigate the differential expression of ECM molecules by microarray analysis. Because matrix metalloproteinases (MMP) showed the highest differential expression in the microarray analysis, MMPs were further examined by in situ zymography and immunohistochemistry. Data were analyzed by using one-way analysis of variance followed by the Tukey test.
resultsWe observed that cysts and granulomas differentially expressed several ECM molecules, especially those from the MMP family. Compared with cysts, granulomas exhibited higher MMP enzymatic activity in areas stained for MMP-9. These areas were composed of polymorphonuclear cells (PMNs) in contrast to cysts. Similarly, MMP-13 was expressed by a greater number of cells in granulomas compared with cysts.
conclusionOur findings indicate that high enzymatic MMP activity in PMNs together with MMP-9 and MMP-13 stained cells could be a molecular signature of granulomas unlike periapical cysts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.