ArticleThe Journal of allergy and clinical immunology2009
Antimicrobial peptides and the skin immune defense system.
Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis.The Journal of dermatology · 2026Review
- Topographical variations in the skin barrier and their role in disease pathogenesis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Distinct anti-microbial peptides expression patterns and microbiome profiles in skin of Tunisian endemic Pemphigus foliaceus patients.Archives of dermatological research · 2025Article
- OBP2A regulates epidermal barrier function and protects against cytotoxic small hydrophobic molecules.iScience · 2024Article
- Between good and evil: Complexation of the human cathelicidin LL-37 with nucleic acids.Biophysical journal · 2024Review
- CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17.The Journal of experimental medicine · 2024Article
- Regulation of LL-37 in Bone and Periodontium Regeneration.Life (Basel, Switzerland) · 2022Review
- From Pre- and Probiotics to Post-Biotics: A Narrative Review.International journal of environmental research and public health · 2021Review
- Lactic acid as a major contributor to hand surface infection barrier and its association with morbidity to infectious disease.Scientific reports · 2021Observational
- Ag@ZnO Nanoparticles Induce Antimicrobial Peptides and Promote Migration and Antibacterial Activity of Keratinocytes.ACS infectious diseases · 2021Article
- A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.EMBO molecular medicine · 2021Article
- Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges.International journal of molecular sciences · 2021Review
- Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry.International journal of molecular sciences · 2021Article
- Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns.Scientific reports · 2021Article
- Postbiotics-A Step Beyond Pre- and Probiotics.Nutrients · 2020Review
- Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors.Acta dermato-venereologica · 2020Review
- Human Defensins: A Novel Approach in the Fight against Skin ColonizingAntibiotics (Basel, Switzerland) · 2020Review
- Temporal development of the infant gut microbiome.Open biology · 2019Article
- Borrelia burgdorferi surface protein Lmp1 facilitates pathogen dissemination through ticks as studied by an artificial membrane feeding system.Scientific reports · 2018Article
- Chlamydial Plasmid-Dependent Pathogenicity.Trends in microbiology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our skin is constantly challenged by microbes but is rarely infected. Cutaneous production of antimicrobial peptides (AMPs) is a primary system for protection, and expression of some AMPs further increases in response to microbial invasion. Cathelicidins are unique AMPs that protect the skin through 2 distinct pathways: (1) direct antimicrobial activity and (2) initiation of a host response resulting in cytokine release, inflammation, angiogenesis, and reepithelialization. Cathelicidin dysfunction emerges as a central factor in the pathogenesis of several cutaneous diseases, including atopic dermatitis, in which cathelicidin is suppressed; rosacea, in which cathelicidin peptides are abnormally processed to forms that induce inflammation; and psoriasis, in which cathelicidin peptide converts self-DNA to a potent stimulus in an autoinflammatory cascade. Recent work identified vitamin D3 as a major factor involved in the regulation of cathelicidin. Therapies targeting control of cathelicidin and other AMPs might provide new approaches in the management of infectious and inflammatory skin diseases.
Identifiers
19720207What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.