ArticleBiophysical journal2009
Force-velocity relation for actin-polymerization-driven motility from Brownian dynamics simulations.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Myosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin.Communications materials · 2024Article
- Collagen fibril assembly: New approaches to unanswered questions.Matrix biology plus · 2021Article
- A continuum model for the growth of dendritic actin networks.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Building a dendritic actin filament network branch by branch: models of filament orientation pattern and force generation in lamellipodia.Biophysical reviews · 2018Review
- Power transduction of actin filaments ratcheting in vitro against a load.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Multiscale modeling of cell shape from the actin cytoskeleton.Progress in molecular biology and translational science · 2014Review
- Control of actin-based motility through localized actin binding.Physical biology · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- Actin filament elasticity and retrograde flow shape the force-velocity relation of motile cells.Biophysical journal · 2012Article
- Mesoscopic model of actin-based propulsion.PLoS computational biology · 2012Article
- Filament depolymerization can explain chromosome pulling during bacterial mitosis.PLoS computational biology · 2011Article
- Force-velocity measurements of a few growing actin filaments.PLoS biology · 2011Article
- Keratocyte lamellipodial protrusion is characterized by a concave force-velocity relation.Biophysical journal · 2011Article
- Observation and kinematic description of long actin tracks induced by spherical beads.Biophysical journal · 2010Article
- Simulation of cell motility that reproduces the force-velocity relationship.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Effects of molecular-scale processes on observable growth properties of actin networks.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Actin dynamics: from nanoscale to microscale.Annual review of biophysics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report numerical simulation results for the force-velocity relation for actin-polymerization-driven motility. We use Brownian dynamics to solve a physically consistent formulation of the dendritic nucleation model with semiflexible filaments that self-assemble and push a disk. We find that at small loads, the disk speed is independent of load, whereas at high loads, the speed decreases and vanishes at a characteristic stall pressure. Our results demonstrate that at small loads, the velocity is controlled by the reaction rates, whereas at high loads the stall pressure is determined by the mechanical properties of the branched actin network. The behavior is consistent with experiments and with our recently proposed self-diffusiophoretic mechanism for actin-polymerization-driven motility. New in vitro experiments to measure the force-velocity relation are proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.