ArticleJournal of neurochemistry2009
Cerebral microvascular IL15 is a novel mediator of TNF action.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- The Mechanisms of Altered Blood-Brain Barrier Permeability in CD19 CAR T-Cell Recipients.International journal of molecular sciences · 2024Review
- Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline.The Journal of experimental medicine · 2020Article
- The blood-brain barrier in neuroimmunology: Tales of separation and assimilation.Brain, behavior, and immunity · 2015Review
- Article
- Sleep restriction impairs blood-brain barrier function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.Brain, behavior, and immunity · 2014Article
- Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3.Fluids and barriers of the CNS · 2013Article
- Brain interleukin-15 in neuroinflammation and behavior.Neuroscience and biobehavioral reviews · 2013Review
- Article
- Brain meets body: the blood-brain barrier as an endocrine interface.Endocrinology · 2012Review
- Cytokine signaling modulates blood-brain barrier function.Current pharmaceutical design · 2011Review
- Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells.Neuroscience letters · 2011Article
- Potential protective role of IL15Rα during inflammation.Journal of molecular neuroscience : MN · 2011Article
- Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice.Journal of molecular neuroscience : MN · 2011Article
- Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.Psychoneuroendocrinology · 2011Article
- Rapid endocytosis of interleukin-15 by cerebral endothelia.Journal of neurochemistry · 2011Article
- NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011Article
- The effects of IL2Rgamma knockout on depression and contextual memory.Behavioural brain research · 2010Article
- Essential role of interleukin-15 receptor in normal anxiety behavior.Brain, behavior, and immunity · 2010Article
- Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier.Journal of neurochemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The blood-brain barrier is a gatekeeper and modulatory interface for the CNS. Cerebral endothelial cells are the major component of the blood-brain barrier, and they modify inflammatory signals from the circulation to the CNS by production and secretion of secondary substances. The inflammatory mediators induced by tumor necrosis factor alpha (TNF) were determined by microarray analysis of RBE4 cerebral endothelial cells, at 0, 6, 12, or 24 h after TNF treatment. Interleukin (IL)-15 and its receptors were among the most robustly up-regulated genes. This was confirmed by real-time RT-PCR and western blotting. The three subunits of the IL15 receptor complex (IL15Ralpha, IL2Rbeta, and IL2Rgamma) showed differential regulation by TNF in their time course and amplitude of increased expression. Consistent with increased expression of the specific high affinity receptor IL15Ralpha, TNF increased cellular uptake of (125)I-IL15 and enhanced the fluorescent intensity of Alexa568-IL15 in RBE4 cells. TNF treatment in mice also increased the level of expression of IL15 receptors in enriched cerebral microvessels. We conclude that the cerebral microvascular IL15 system is a novel inflammatory mediator that transduces the actions of TNF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.