ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Myosin-X is required for cranial neural crest cell migration in Xenopus laevis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Cells stably expressing shRNA against MYO10 display altered cell motility.microPublication biology · 2025Article
- Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis ofHGG advances · 2023Article
- Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Myosin 10 is involved in murine pigmentation.Experimental dermatology · 2019Article
- Phenotypic analysis of Myo10 knockout (Myo10Scientific reports · 2019Article
- Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.Scientific reports · 2018Article
- Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.Scientific reports · 2017Article
- Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus.Scientific reports · 2016Article
- Myosin-X and disease.Experimental cell research · 2015Review
- Myosin X regulates neuronal radial migration through interacting with N-cadherin.Frontiers in cellular neuroscience · 2015Article
- Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Dissection of Xenopus laevis neural crest for in vitro explant culture or in vivo transplantation.Journal of visualized experiments : JoVE · 2014Article
- Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.The Journal of clinical investigation · 2014Article
- Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons.The Journal of biological chemistry · 2012Article
- Differential regulation of myosin X movements by its cargos, DCC and neogenin.Journal of cell science · 2012Article
- Myosin-X: a MyTH-FERM myosin at the tips of filopodia.Journal of cell science · 2011Review
- Structural basis of the myosin X PH1(N)-PH2-PH1(C) tandem as a specific and acute cellular PI(3,4,5)P(3) sensor.Molecular biology of the cell · 2011Article
- Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cranial neural crest migration: new rules for an old road.Developmental biology · 2010Review
- Mechanism of Xenopus cranial neural crest cell migration.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Myosin-X (MyoX) belongs to a large family of unconventional, nonmuscle, actin-dependent motor proteins. We show that MyoX is predominantly expressed in cranial neural crest (CNC) cells in embryos of Xenopus laevis and is required for head and jaw cartilage development. Knockdown of MyoX expression using antisense morpholino oligonucleotides resulted in retarded migration of CNC cells into the pharyngeal arches, leading to subsequent hypoplasia of cartilage and inhibited outgrowth of the CNC-derived trigeminal nerve. In vitro migration assays on fibronectin using explanted CNC cells showed significant inhibition of filopodia formation, cell attachment, spreading and migration, accompanied by disruption of the actin cytoskeleton. These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.