ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
The transcription factor D-Pax2 regulates crystallin production during eye development in Drosophila melanogaster.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- PAX8 Expression in the Crystalline Lens and Lens-Derived Lesions.Ophthalmology science · 2021Article
- A Complex Lens for a Complex Eye.Integrative and comparative biology · 2017Article
- Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways.Scientific reports · 2017Article
- The cuticular nature of corneal lenses in Drosophila melanogaster.Development genes and evolution · 2017Article
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
- Controlled expression of Drosophila homeobox loci using the Hostile takeover system.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- The lens in focus: a comparison of lens development in Drosophila and vertebrates.Molecular genetics and genomics : MGG · 2011Review
- Rapid evolutionary rewiring of a structurally constrained eye enhancer.Current biology : CB · 2011Article
- Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.Current topics in developmental biology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The generation of a functioning Drosophila eye requires the coordinated differentiation of multiple cell types and the morphogenesis of eye-specific structures. Here we show that D-Pax2 plays a significant role in lens development through regulation of the Crystallin gene and because Crystallin is also expressed in D-Pax2(+) cells in the external sensory organs. Loss of D-Pax2 function leads to loss of Crystallin expression in both eyes and bristles. A 2.3 kilobase (kb) upstream region of the Crystallin gene can drive GFP expression in the eye and is dependent on D-Pax2. In addition, D-Pax2 binds to an evolutionarily conserved site in this region that, by itself, is sufficient to drive GFP expression in the eye. However, mutation of this site does not greatly affect the regulatory region's function. The data indicate that D-Pax2 acts to promote lens development by controlling the production of the major protein component of the lens. Whether this control is direct or indirect remains unresolved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.