ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2009
Redefining resection margin status in pancreatic cancer.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03340844 (Role of Circulating Tumor Cells), which is not on this map. Cited by 87 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Circulating Tumor Cells (CTC´s) Spread During Pancreaticoduodenectomy in Metastasis and Survival Rates in Patients With Pancreatic and Periampullary Tumors
Who cites it
87 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Impact of intraoperative margin clearance on survival following pancreatoduodenectomy for pancreatic cancer: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Impact of Resection Margin Distance on Survival of Pancreatic Cancer: A Systematic Review and Meta-Analysis.Cancer research and treatment · 2017Pooled it
- Endoluminal and Interstitial Brachytherapy for the Treatment of Gastrointestinal Malignancies: a Systematic Review.Current oncology reports · 2017Pooled it
- Trial
- Routine CT reporting of vascular involvement in pancreatic ductal adenocarcinoma: completeness and association with margin-positive resection.Abdominal radiology (New York) · 2026Article
- Area-based centralization of pancreatic surgery: a Hub-and-Spoke system balances patient proximity and quality of care.Updates in surgery · 2026Article
- Radiologic-pathologic discrepancy in the tumor size assessment of pancreatic ductal adenocarcinoma in the era of preoperative therapy.Surgery today · 2026Review
- Pancreatic Cancer Frequently Infiltrates the TRIANGLE Compartment: A Surgical Option to Prevent Local Recurrence.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Article
- Status of Lymph Node Metastasis and Efficacy of Lymph Node Dissection Along the Superior Mesenteric Artery in Pancreatic Head Cancer: Clinicopathological Analysis of Patients Undergoing Pancreatoduodenectomy With Circumferential Lymph Nodes Dissection Along the Superior Mesenteric Artery.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Article
- From open to robotic distal pancreatectomy: the learning curve and mastering benchmark outcomes in a Scandinavian high volume center.Langenbeck's archives of surgery · 2025Article
- Laparoscopic versus open pancreaticoduodenectomy for pancreatic or periampullary tumors: a multicenter propensity score-matched comparative study.Surgical endoscopy · 2025Article
- DNA Origami-Cyanine Nanocomplex for Precision Imaging of KRAS-Mutant Pancreatic Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Prognostic value of the CRM-status in pancreatic ductal adenocarcinoma - data from a regional cancer registry.BMC cancer · 2024Article
- The Relationship between Treatment Response and Overall Survival in Borderline, Non-Resectable and Resectable Pancreatic Cancer Patients Treated with Neoadjuvant FOLFIRINOX.Journal of clinical medicine · 2024Article
- Imaging of pancreatic ductal adenocarcinoma - An update for all stages of patient management.European journal of radiology open · 2024Article
- ASO Practice Guidelines Series: Management of Resectable, Borderline Resectable, and Locally Advanced Pancreas Cancer.Annals of surgical oncology · 2024Review
- The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients.Nature cancer · 2024Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curative resection is crucial to survival in pancreatic cancer; however, despite optimization and standardization of surgical procedures, this is not always achieved. This review highlights that the rates of microscopic margin involvement (R1) vary markedly between studies and, although resection margin status is believed to be a key prognostic factor, the rates of margin involvement and local tumour recurrence or overall survival of pancreatic cancer patients are often incongruent. Recent studies indicate that the discrepancy between margin status and clinical outcome is caused by frequent underreporting of microscopic margin involvement. Lack of standardization of pathological examination, confusing nomenclature and controversy regarding the definition of microscopic margin involvement have resulted in the wide variation of reported R1 rates that precludes meaningful comparison of data and clinicopathological correlation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.