Evidence map›Paper›PMID 19718044›Full record

ArticleOncogene2009

The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation.

K M Shah, S E Stewart, W Wei, C B J Woodman, J D O'Neil, C W Dawson, L S Young

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

K M ShahCancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, Birmingham, UK.
S E Stewart
W Wei
C B J Woodman
J D O'Neil
C W Dawson
L S Young
Cancer Research UK · GBUniversity of Birmingham · GBUniversity of Edinburgh · GB

Funding

Cancer Research UK A3916
6 · The paper itself

Abstract

Although frequently expressed in Epstein-Barr virus (EBV)-positive malignancies, the role that latent membrane protein 2A and 2B (LMP2A and LMP2B) have in the oncogenic process remains obscure. Here we show a novel function for these proteins in epithelial cells, namely, their ability to modulate signalling from type I/II interferon receptors (IFNRs). We show that LMP2A- and LMP2B-expressing epithelial cells show decreased responsiveness to interferon (IFN)alpha and IFNgamma, as assessed by STAT1 phosphorylation, ISGF3 and GAF-mediated binding to IFN-stimulated response element and IFNgamma-activated factor sequence elements and luciferase reporter activation. Transcriptional profiling highlighted the extent of this modulation, with both viral proteins impacting 'globally' on IFN-stimulated gene expression. Although not affecting the levels of cell-surface IFNRs, LMP2A and LMP2B accelerated the turnover of IFNRs through processes requiring endosome acidification. This function may form part of EBV's strategy to limit anti-viral responses and define a novel function for LMP2A and LMP2B in modulating signalling from receptors that participate in innate immune responses.

Indexed as

Cell LineEndosomesEpithelial CellsEpstein-Barr Virus InfectionsGene Expression RegulationHerpesvirus 4, HumanHumansImmunity, InnateInterferon-alphaInterferon-gammaInterferon-Stimulated Gene Factor 3, gamma SubunitOncogene Proteins, ViralReceptors, InterferonResponse ElementsSignal TransductionSTAT1 Transcription FactorEBV-associated membrane antigen, Epstein-Barr virusInterferon-alphaInterferon-gammaInterferon-Stimulated Gene Factor 3, gamma SubunitIRF9 protein, humanOncogene Proteins, ViralReceptors, InterferonSTAT1 protein, humanSTAT1 Transcription FactorViral Matrix Proteins

Identifiers

PMID19718044
PMCPMC2774296
OpenAlexW2005049291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.