ArticleJournal of visualized experiments : JoVE2009
Bioluminescence imaging of heme oxygenase-1 upregulation in the Gua Sha procedure.
Article in Journal of visualized experiments : JoVE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821194 (The Effect of Chronic Pain Relief Over Knee Joint Area by Gua Sha Therapy), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Chronic Pain Relief Over Knee Joint Area by Gua Sha Therapy
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Clinical and Animal Studies of Waist and Knee Scraping Therapy for Knee Osteoarthritis.Combinatorial chemistry & high throughput screening · 2024Trial
- Individual vs. Group Delivery of Acupuncture Therapy for Chronic Musculoskeletal Pain in Urban Primary Care-a Randomized Trial.Journal of general internal medicine · 2020Trial
- The influence of a series of five dry cupping treatments on pain and mechanical thresholds in patients with chronic non-specific neck pain--a randomised controlled pilot study.BMC complementary and alternative medicine · 2011Trial
- Mechanisms Underlying the Beneficial Effects of Scraping Therapy: A Review of Articles.Cureus · 2026Review
- Effect of myofascial cupping vs integrated neuromuscular inhibition techniques on pain and neck movement in individuals with latent trigger point in trapezius.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2023Article
- Misreport of burns as a result of 'coining', Gua sha; inherent harms from publication and ongoing citation of false facts.Integrative medicine research · 2023Article
- Exploring scraping therapy: Contemporary views on an ancient healing - A review.Journal of family medicine and primary care · 2021Review
- The role of carbon monoxide and heme oxygenase-1 in COVID-19.Toxicology reports · 2020Article
- Self-Myofascial Vibro-Shearing: a Randomized Controlled Trial of Biomechanical and Related Changes in Male Breakdancers.Sports medicine - open · 2018Article
- Gua Sha, a press-stroke treatment of the skin, boosts the immune response to intradermal vaccination.PeerJ · 2016Article
- Combination treatment with Gua Sha and Blood-letting causes attenuation of systemic inflammation, activated coagulation, tissue ischemia and injury during heatstroke in rats.Chinese journal of integrative medicine · 2015Article
- Effects of GUASHA on Heart Rate Variability in Healthy Male Volunteers under Normal Condition and Weightlifters after Weightlifting Training Sessions.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Gua Sha, an ancient technical management, for certain illness.Chinese journal of integrative medicine · 2013Article
- Culture-Bounded Skin Lesion - A Case Due to Chinese Gua Sha.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gua Sha is a traditional Chinese folk therapy that employs skin scraping to cause subcutaneous microvascular blood extravasation and bruises. The protocol for bioluminescent optical imaging of HO-1-luciferase transgenic mice reported in this manuscript provides a rapid in vivo assay of the upregulation of the heme oxygenase-1 (HO-1) gene expression in response to the Gua Sha procedure. HO-1 has long been known to provide cytoprotection against oxidative stress. The upregulation of HO-1, assessed by the bioluminescence output, is thought to represent an antioxidative response to circulating hemoglobin products released by Gua Sha. Gua Sha was administered by repeated strokes of a smooth spoon edge over lubricated skin on the back or other targeted body part of the transgenic mouse until petechiae (splinter hemorrhages) or ecchymosis (bruises) indicative of extravasation of blood from subcutaneous capillaries was observed. After Gua Sha, bioluminescence imaging sessions were carried out daily for several days to follow the dynamics of HO-1 expression in multiple internal organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.