Trial reportJournal of the American Medical Informatics Association : JAMIA
The influence that electronic prescribing has on medication errors and preventable adverse drug events: an interrupted time-series study.
Trial report in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Reducing medication errors for adults in hospital settings.The Cochrane database of systematic reviews · 2021Pooled it
- How effective are electronic medication systems in reducing medication error rates and associated harm among hospital inpatients? A systematic review and meta-analysis.Journal of the American Medical Informatics Association : JAMIA · 2021Pooled it
- The impact of health information technology on prescribing errors in hospitals: a systematic review and behaviour change technique analysis.Systematic reviews · 2020Pooled it
- Use of interrupted time series methods in the evaluation of health system quality improvement interventions: a methodological systematic review.BMJ global health · 2020Pooled it
- Effect of Electronic Prescribing Strategies on Medication Error and Harm in Hospital: a Systematic Review and Meta-analysis.Journal of general internal medicine · 2019Pooled it
- Pooled it
- The effectiveness of computerized order entry at reducing preventable adverse drug events and medication errors in hospital settings: a systematic review and meta-analysis.Systematic reviews · 2014Pooled it
- The effects of on-screen, point of care computer reminders on processes and outcomes of care.The Cochrane database of systematic reviews · 2009Pooled it
- Electronic health record intervention to increase use of NSAIDs as analgesia for hospitalised patients: a cluster randomised controlled study.BMJ health & care informatics · 2023Trial
- A behavioral intervention to promote use of multimodal pain medication for hospitalized patients: A randomized controlled trial.Journal of hospital medicine · 2023Trial
- Electronic prescribing and patient safety: a rigour-stratified systematic review of medication error, adverse drug events, workflow, and communication.Exploratory research in clinical and social pharmacy · 2026Review
- Factors associated with chronic pain clinical decision support use in primary care.PLOS digital health · 2026Article
- Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.European journal of hospital pharmacy : science and practice · 2024Article
- Harnessing the power of clinical decision support systems: challenges and opportunities.Open heart · 2023Review
- Assessment of the operation status of electronic prescription at community pharmacies in Chengdu, China: a simulated patient study.BMC health services research · 2023Article
- The impact of transition to a digital hospital on medication errors (TIME study).NPJ digital medicine · 2023Article
- End-users feedback and perceptions associated with the implementation of a clinical-rule based Check of Medication Appropriateness service.BMC medical informatics and decision making · 2022Article
- Antimicrobial stewardship using electronic prescribing systems in hospital settings: a scoping review of interventions and outcome measures.JAC-antimicrobial resistance · 2022Article
- Article
- Interventions to reduce medication errors in adult medical and surgical settings: a systematic review.Therapeutic advances in drug safety · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluated the effect of a Computerized Physician Order Entry system with basic Clinical Decision Support (CPOE/CDSS) on the incidence of medication errors (MEs) and preventable adverse drug events (pADEs).
designInterrupted time-series design. MEASUREMENTS: The primary outcome measurements comprised the percentage of medication orders with one or more MEs and the percentage of patients with one or more pADEs.
resultsPre-implementation, the mean percentage of medication orders containing at least one ME was 55%, whereas this became 17% post-implementation. The introduction of CPOE/CDSS has led to a significant immediate absolute reduction of 40.3% (95% CI: -45.13%; -35.48%) in medication orders with one or more errors. Pre-implementation, the mean percentage of admitted patients experiencing at least one pADE was 15.5%, as opposed to 7.3% post-implementation. However, this decrease could not be attributed to the introduction of CPOE/CDSS: taking into consideration the interrupted time-series design, the immediate change was not significant (-0.42%, 95% CI: -15.52%; 14.68%) because of the observed underlying negative trend during the pre-CPOE period of -4.04% [95% CI: -7.70%; -0.38%] per month.
conclusionsThis study has shown that CPOE/CDSS reduces the incidence of medication errors. However, a direct effect on actual patient harm (pADEs) was not demonstrated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.