ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men.Frontiers in physiology · 2023Article
- Topical Analgesic Containing Methyl Salicylate and L-Menthol Accelerates Heat Loss During Skin Cooling for Exercise-Induced Hyperthermia.Frontiers in physiology · 2022Article
- Influences of ovarian hormones on physiological responses to cold in women.Temperature (Austin, Tex.) · 2022Review
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension.The Journal of physiology · 2017Article
- Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Sympathetic control of reflex cutaneous vasoconstriction in human aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans.Microvascular research · 2013Article
- Exercise training and the control of skin blood flow in older adults.The journal of nutrition, health & aging · 2012Review
- Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Cutaneous sympathetic neural responses to body cooling in type 2 diabetes mellitus.Autonomic neuroscience : basic & clinical · 2011Article
- Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Thermal provocation to evaluate microvascular reactivity in human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.The Journal of physiology · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Primary human aging may be associated with augmented Rho kinase (ROCK)-mediated contraction of vascular smooth muscle and ROCK-mediated inhibition of nitric oxide synthase (NOS). We hypothesized that the contribution of ROCK to reflex vasoconstriction (VC) is greater in aged skin. Cutaneous VC was elicited by 1) whole body cooling [mean skin temperature (T(sk)) = 30.5 degrees C] and 2) local norepinephrine (NE) infusion (1 x 10(-6) M). Four microdialysis fibers were placed in the forearm skin of eight young (Y) and eight older (O) subjects for infusion of 1) Ringer solution (control), 2) 3 mM fasudil (ROCK inhibition), 3) 20 mM N(G)-nitro-l-arginine methyl ester (NOS inhibition), and 4) both ROCK + NOS inhibitors. Red cell flux was measured by laser-Doppler flowmetry over each site. Cutaneous vascular conductance (CVC) was calculated as flux/mean arterial pressure and normalized to baseline CVC (%DeltaCVC(baseline)). VC was reduced at the control site in O during cooling (Y, -34 + or - 3; and O, -18 + or - 3%DeltaCVC(baseline); P < 0.001) and NE infusion (Y, -53 + or - 4, and O, -41 + or - 9%DeltaCVC(baseline); P = 0.006). Fasudil attenuated VC in both age groups during mild cooling; however, this reduction remained only in O but not in Y skin during moderate cooling (Y, -30 + or - 5; and O, -7 + or - 1%DeltaCVC(baseline); P = 0.016) and was not altered by NOS inhibition. Fasudil blunted NE-mediated VC in both age groups (Y, -23 + or - 4; and O, -7 + or - 3%DeltaCVC(baseline); P < 0.01). Cumulatively, these data indicate that reflex VC is more reliant on ROCK in aged skin such that approximately half of the total VC response to whole body cooling is ROCK dependent.
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Registered trials
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