ArticleThe Journal of experimental biology2009
Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includens.
Article in The Journal of experimental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- A chromosome-scale genome assembly and functional studies implicate the viral RNA polymerase in transcription of most Microplitis demolitor bracovirus late genes.Journal of virology · 2026Article
- Lipid Metabolism in Parasitoids and Parasitized Hosts.Advances in experimental medicine and biology · 2026Review
- Convergence in Symbiont-Induced Plant-Mediated Responses to Herbivory: Cascading Effects for Foraging Parasitoids.Ecology letters · 2025Article
- Symbiotic bracovirus of a parasite modulate host ecdysis process.Cellular and molecular life sciences : CMLS · 2025Article
- The vitellogenin receptor gene contributes to mating and host-searching behaviors in parasitoid wasps.iScience · 2023Article
- Evolution of koinobiont parasitoid host regulation and consequences for indirect plant defence.Evolutionary ecology · 2022Review
- MdBVe46 is an envelope protein that is required for virion formation by Microplitis demolitor bracovirus.The Journal of general virology · 2021Article
- MicroRNAs from Snellenius manilae bracovirus regulate innate and cellular immune responses of its host Spodoptera litura.Communications biology · 2021Article
- Parasitoid Causes Cascading Effects on Plant-Induced Defenses Mediated Through the Gut Bacteria of Host Caterpillars.Frontiers in microbiology · 2021Article
- Regulation of the Larval Transcriptome ofFrontiers in physiology · 2019Article
- Cotesia congregata Bracovirus Circles EncodingJournal of virology · 2018Article
- Proximal Remote Sensing to Non-destructively Detect and Diagnose Physiological Responses by Host Insect Larvae to Parasitism.Frontiers in physiology · 2018Article
- Calcium influx enhances neuropeptide activation of ecdysteroid hormone production by mosquito ovaries.Insect biochemistry and molecular biology · 2016Article
- The endoparasitoid, Cotesia vestalis, regulates host physiology by reprogramming the neuropeptide transcriptional network.Scientific reports · 2015Article
- Systematic analysis of a wasp parasitism arsenal.Molecular ecology · 2014Article
- Accidental genetic engineers: horizontal sequence transfer from parasitoid wasps to their Lepidopteran hosts.PloS one · 2014Article
- A polydnavirus ANK protein acts as virulence factor by disrupting the function of prothoracic gland steroidogenic cells.PloS one · 2014Article
- Two's a crowd: phenotypic adjustments and prophylaxis in Anticarsia gemmatalis larvae are triggered by the presence of conspecifics.PloS one · 2013Article
- The encapsidated genome of Microplitis demolitor bracovirus integrates into the host Pseudoplusia includens.Journal of virology · 2011Article
- Deep sequencing-based transcriptome analysis of Plutella xylostella larvae parasitized by Diadegma semiclausum.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Insect pathogens and parasites often affect the growth and development of their hosts, but understanding of these processes is fragmentary. Among the most species-rich and important mortality agents of insects are parasitoid wasps that carry symbiotic polydnaviruses (PDVs). Like many PDV-carrying wasps, Microplitis demolitor inhibits growth and pupation of its lepidopteran host, Pseudoplusia includens, by causing host hemolymph juvenile hormone (JH) titers to remain elevated and preventing ecdysteroid titers from rising. Here we report these alterations only occurred if P. includens was parasitized prior to achieving critical weight, and were fully mimicked by infection with only M. demolitor bracovirus (MdBV). Metabolic assays revealed that MdBV infection of pre-critical weight larvae caused a rapid and persistent state of hyperglycemia and reduced nutrient stores. In vitro ecdysteroid assays further indicated that prothoracic glands from larvae infected prior to achieving critical weight remained in a refractory state of ecdysteroid release, whereas infection of post-critical weight larvae had little or no effect on ecdysteroid release by prothoracic glands. Taken together, our results suggest MdBV causes alterations in metabolic physiology, which prevent the host from achieving critical weight. This in turn inhibits the endocrine events that normally trigger metamorphosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.