ArticleThe Journal of biological chemistry2009
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Gut microbes and their metabolites in relation to the classic tumor suppressor gene P53: a novel narrative.NPJ biofilms and microbiomes · 2025Review
- Hemichordate cis-regulatory genomics and the gene expression dynamics of deuterostomes.Nature ecology & evolution · 2024Article
- Cooperation of TGF-β and FGF signalling pathways in skin development.Cell proliferation · 2023Review
- Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair.Stem cells translational medicine · 2023Review
- ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling.Epigenetics & chromatin · 2021Article
- Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis.International journal of molecular sciences · 2019Review
- Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification.Nature communications · 2019Article
- Master regulatory role of p63 in epidermal development and disease.Cellular and molecular life sciences : CMLS · 2018Review
- Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.EMBO reports · 2018Article
- p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation.Cell death and differentiation · 2017Article
- Cbx4: A new guardian of p63's domain of epidermal control.The Journal of cell biology · 2016Article
- Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.The Journal of cell biology · 2016Article
- p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis.Experimental dermatology · 2015Article
- A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.Nucleic acids research · 2015Article
- p53/p63/p73 in the epidermis in health and disease.Cold Spring Harbor perspectives in medicine · 2014Review
- Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells.BMC genomics · 2014Article
- Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins.The Journal of biological chemistry · 2013Article
- p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.Human molecular genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
p63, a p53 family member, plays an essential role in epidermal development by regulating its transcriptional program. Here we report a previously uncovered role of p63 in controlling bone morphogenetic protein (BMP) signaling, which is required for maintaining low expression levels of several non-epidermal genes. p63 represses transcription of the inhibitory Smad7 and activates Bmp7, thereby sustaining BMP signaling. In the absence of p63, compromised BMP signaling leads to inappropriate non-epidermal gene expression in postnatal mouse keratinocytes and in embryonic epidermis. Reactivation of BMP signaling by Smad7 knockdown and/or, to a lesser extent, by BMP treatment suppresses expression of non-epidermal genes in the absence of p63. Canonical BMP/Smad signaling is essential for control of non-epidermal genes as use of a specific inhibitor, or simultaneous knockdown of Smad1 and Smad5 counteract suppression of non-epidermal genes. Our data indicate that p63 prevents ectopic expression of non-epidermal genes by a mechanism involving Smad7 repression and, to a lesser extent, Bmp7 induction, with consequent enhancement of BMP/Smad signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.