ArticleMolecular biology and evolution2009
Global microsatellite content distinguishes humans, primates, animals, and plants.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed.
- Population Genetic Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Conserved microsatellites may contribute to stem-loop structures in 5', 3' terminals of Ebolavirus genomes.Biochemical and biophysical research communications · 2019Article
- Patterns of microsatellite distribution across eukaryotic genomes.BMC genomics · 2019Article
- Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites.DNA repair · 2015Article
- Patterns of microsatellite evolution inferred from the Helianthus annuus (Asteraceae) transcriptome.Journal of genetics · 2014Article
- Life cycle of an n-globin pseudogene microsatellite locus.Frontiers in genetics · 2013Article
- Patterns of evolutionary conservation of microsatellites (SSRs) suggest a faster rate of genome evolution in Hymenoptera than in Diptera.Genome biology and evolution · 2013Article
- Breakdown of phylogenetic signal: a survey of microsatellite densities in 454 shotgun sequences from 154 non model eukaryote species.PloS one · 2012Article
- A species independent universal bio-detection microarray for pathogen forensics and phylogenetic classification of unknown microorganisms.BMC microbiology · 2011Article
- Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature.Genes, chromosomes & cancer · 2011Article
- Article
- Cgaln: fast and space-efficient whole-genome alignment.BMC bioinformatics · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Microsatellites are highly mutable, repetitive sequences commonly used as genetic markers, but they have never been studied en masse. Using a custom microarray to measure hybridization intensities of every possible repetitive nucleotide motif from 1-mers to 6-mers, we examined 25 genomes. Here, we show that global microsatellite content varies predictably by species, as measured by array hybridization signal intensities, correlating with established taxonomic relationships, and particular motifs are characteristic of one species versus another. For instance, hominid-specific microsatellite motifs were identified despite alignment of the human reference, Celera, and Venter genomic sequences indicating substantial variation (30-50%) among individuals. Differential microsatellite motifs were mainly associated with genes involved in developmental processes, whereas those found in intergenic regions exhibited no discernible pattern. This is the first description of a method for evaluating microsatellite content to classify individual genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.