ArticleProceedings of the National Academy of Sciences of the United States of America2009
A role for galanin in human and experimental inflammatory demyelination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Intranasal Delivery of a Methyllanthionine-Stabilized Galanin Receptor-2-Selective Agonist Reduces Acute Food Intake.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Neuroimmunomodulation by gut bacteria: Focus on inflammatory bowel diseases.World journal of gastrointestinal pathophysiology · 2021Review
- Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae.Biology · 2021Article
- Insights into Potential Targets for Therapeutic Intervention in Epilepsy.International journal of molecular sciences · 2020Review
- The use and limitations of single-cell mass cytometry for studying human microglia function.Brain pathology (Zurich, Switzerland) · 2020Review
- Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis.Acta neuropathologica communications · 2020Article
- Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype.Cell death & disease · 2020Article
- Influence of the regulatory peptide galanin on cytokine expression in human monocytes.Annals of the New York Academy of Sciences · 2019Article
- Subclinical lipopolysaccharide from Salmonella Enteritidis induces neuropeptide dysregulation in the spinal cord and the dorsal root ganglia.BMC neuroscience · 2019Article
- A non-functional galanin receptor-2 in a multiple sclerosis patient.The pharmacogenomics journal · 2019Article
- A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis.CNS neuroscience & therapeutics · 2018Article
- Temporal-Spatial Profiling of Pedunculopontine Galanin-Cholinergic Neurons in the Lactacystin Rat Model of Parkinson's Disease.Neurotoxicity research · 2018Article
- Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis.Neuroscience · 2017Article
- Murine Cytomegalovirus Infection Induces Susceptibility to EAE in Resistant BALB/c Mice.Frontiers in immunology · 2017Article
- Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression.Molecular medicine (Cambridge, Mass.) · 2016Article
- Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis.Journal of neuroimmunology · 2014Article
- G protein-coupled receptors as therapeutic targets for multiple sclerosis.Cell research · 2012Review
- Generating orally active galanin analogues with analgesic activities.ChemMedChem · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
The neuropeptide galanin is widely expressed by many differing subsets of neurons in the nervous system. There is a marked upregulation in the levels of the peptide in a variety of nerve injury models and in the basal forebrain of humans with Alzheimer's disease. Here we demonstrate that galanin expression is specifically and markedly upregulated in microglia both in multiple sclerosis (MS) lesions and shadow plaques. Galanin expression is also upregulated in the experimental autoimmune encephalomyelitis (EAE) model of MS, although solely in oligodendrocytes. To study whether the observed increase in expression of galanin in inflammatory demyelination might modulate disease activity, we applied the EAE model to a panel of galanin transgenic lines. Over-expression of galanin in transgenic mice (Gal-OE) abolishes disease in the EAE model, whilst loss-of-function mutations in galanin or galanin receptor-2 (GalR2) increase disease severity. The pronounced effects of altered endogenous galanin or GalR2 expression on EAE disease activity may reflect a direct neuroprotective effect of the neuropeptide via activation of GalR2, similar to that previously described in a number of neuronal injury paradigms. Irrespective of the mechanism(s) by which galanin alters EAE disease activity, our findings imply that galanin/GalR2 agonists may have future therapeutic implications for MS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.