Evidence map›Paper›PMID 19717451›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2009

Rip exposed: how ectodomain shedding regulates the proteolytic processing of transmembrane substrates.

Daniel R Dries, Gang Yu

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Membrane proteases in the bacterial protein secretion and quality control pathway.Microbiology and molecular biology reviews : MMBR · 2012
    Review
  3. New insights into S2P signaling cascades: regulation, variation, and conservation.Protein science : a publication of the Protein Society · 2010
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel R DriesDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Gang Yu
The University of Texas Southwestern Medical Center · US

Funding

Biochemistry of Nicastrin in the Gamma-Secretase ComplexR01AG023104 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI YU, GANG · 2004 to 2008
$1.5M
Mechanism and Function of Sequential Proteolysis in Health and DiseaseR01AG029547 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI YU, GANG · 2007 to 2010
$1.1M
gamma-Secretase: The First Enzymology-Based Study of Intramembrane ProteolysisF32AG031625 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DRIES, DANIEL R. · 2007 to 2009
$148k
NIA NIH HHS F32 AG031625NIA NIH HHS R01 AG023104NIA NIH HHS R01 AG029547
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino AcidsAmyloid Precursor Protein SecretasesCell MembraneEndopeptidasesEscherichia coliEscherichia coli ProteinsHydrophobic and Hydrophilic InteractionsMembrane ProteinsSubstrate SpecificityTranscription FactorsAmino AcidsAmyloid Precursor Protein SecretasesdegS protein, Escherichia coliEndopeptidasesEscherichia coli ProteinsMembrane ProteinsRseA protein, E coliRseP protein, E coliTranscription Factors

Identifiers

PMID19717451
PMCPMC2736421
OpenAlexW2112742554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.