ArticleProceedings of the National Academy of Sciences of the United States of America2009
A method for nanofluidic device prototyping using elastomeric collapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Hydromechanical Modulation of Enzymatic Kinetics Using Microfluidically Configurable Nanoconfinement Arrays.ACS central science · 2024Article
- Recent Advancements in Nanophotonics for Optofluidics.Advances in physics: X · 2024Article
- Microfluidic Lab-on-a-Chip for Studies of Cell Migration under Spatial Confinement.Biosensors · 2022Review
- Eco friendly nanofluidic platforms using biodegradable nanoporous materials.Scientific reports · 2021Article
- Lithography Technology for Micro- and Nanofabrication.Advances in experimental medicine and biology · 2021Article
- Nanofluidic-Based Accumulation of Antigens for Miniaturized Immunoassay.Sensors (Basel, Switzerland) · 2020Article
- Microfluidic Long-Term Gradient Generator with Axon Separation Prototyped by 185 nm Diffused Light Photolithography of SU-8 Photoresist.Micromachines · 2018Article
- Non-lithographic nanofluidic channels with precisely controlled circular cross sections.RSC advances · 2018Article
- Towards clinically translatableNature reviews. Materials · 2017Article
- Soft electrostatic trapping in nanofluidics.Microsystems & nanoengineering · 2017Article
- Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles.Journal of visualized experiments : JoVE · 2016Article
- Controlled mud-crack patterning and self-organized cracking of polydimethylsiloxane elastomer surfaces.Scientific reports · 2015Article
- Fabrication of nanochannels on polystyrene surface.Biomicrofluidics · 2015Article
- Surface charge, electroosmotic flow and DNA extension in chemically modified thermoplastic nanoslits and nanochannels.The Analyst · 2015Article
- Rapid Prototyping of Nanofluidic Slits in a Silicone Bilayer.Journal of research of the National Institute of Standards and Technology · 2015Article
- Creating sub-50 nm nanofluidic junctions in a PDMS microchip via self-assembly process of colloidal silica beads for electrokinetic concentration of biomolecules.Lab on a chip · 2014Article
- Stretching of DNA confined in nanochannels with charged walls.Biomicrofluidics · 2014Article
- Toward integrated molecular diagnostic system (i MDx): principles and applications.IEEE transactions on bio-medical engineering · 2014Review
- Ultrasensitive surface-enhanced Raman scattering flow detector using hydrodynamic focusing.Analytical chemistry · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
Nanofluidics represents a promising solution to problems in fields ranging from biomolecular analysis to optical property tuning. Recently a number of simple nanofluidic fabrication techniques have been introduced that exploit the deformability of elastomeric materials like polydimethylsiloxane (PDMS). These techniques are limited by the complexity of the devices that can be fabricated, which can only create straight or irregular channels normal to the direction of an applied strain. Here, we report a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures. As is demonstrated, this method converts the easy to control vertical dimension of a PDMS mold to the lateral dimension of a nanochannel. We demonstrate here the creation of complex nanochannel structures as small as 60 nm and provide simple design rules for determining the conditions under which nanochannel formation will occur. The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.