Trial reportDrug and alcohol dependence2009
Naltrexone for the treatment of alcohol dependence among African Americans: results from the COMBINE Study.
Trial report in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Combined pharmacological and psychosocial interventions for alcohol use disorder.The Cochrane database of systematic reviews · 2025Pooled it
- Pharmacological Treatment of Alcohol use Disorder in Patients with Psychotic Disorders: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Secondary analysis of a combined harm-reduction treatment and extended-release naltrexone randomized clinical trial for alcohol use disorder: Differences across race, ethnicity and sex assigned at birth.Addiction (Abingdon, England) · 2026Trial
- Correlates of post-hospitalization naltrexone adherence for alcohol use disorder.Drug and alcohol dependence · 2024Trial
- Effects of arousal modulation via resonance breathing on craving and affect in women with substance use disorder.Addictive behaviors · 2022Trial
- Reduction in Drinking was Associated With Improved Clinical Outcomes in Women With HIV Infection and Unhealthy Alcohol Use: Results From a Randomized Clinical Trial of Oral Naltrexone Versus Placebo.Alcoholism, clinical and experimental research · 2019Trial
- Extended-release vs. oral naltrexone for alcohol dependence treatment in primary care (XON).Contemporary clinical trials · 2019Trial
- Examining naltrexone and alcohol effects in a minority population: results from an initial human laboratory study.The American journal on addictionsTrial
- Intravenous ketamine for severe alcohol use disorder at Moi Teaching & Referral Hospital, Kenya: a case report.Substance abuse treatment, prevention, and policy · 2023Article
- Blood glutamine synthetase signaling in alcohol use disorder and racial disparity.Translational psychiatry · 2022Article
- Leveraging genetic ancestry to study health disparities.American journal of physical anthropology · 2021Article
- Individual and county-level variation in outcomes following non-fatal opioid-involved overdose.Journal of epidemiology and community health · 2020Article
- Lack of Association between Opioid-Receptor Genotypes and Smoking Cessation Outcomes in a Randomized, Controlled Naltrexone Trial.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity.The American journal on addictions · 2017Review
- Efficacy of Naltrexone for the Treatment of Alcohol Dependence in Latino Populations.Journal of studies on alcohol and drugs · 2017Article
- Advances in Substance Abuse Prevention and Treatment Interventions Among Racial, Ethnic, and Sexual Minority Populations.Alcohol research : current reviews · 2016Review
- Genetic ancestry as an effect modifier of naltrexone in smoking cessation among African Americans: an analysis of a randomized controlled trial.Pharmacogenetics and genomics · 2015Article
- Less drinking, yet more problems: understanding African American drinking and related problems.Psychological bulletin · 2014Review
- Variation in Mu-Opioid Receptor GeneJournal of alcoholism and drug dependence · 2013Article
- Human laboratory paradigms in alcohol research.Alcoholism, clinical and experimental research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
These analyses of the COMBINE Study were designed to examine the effects of naltrexone among African Americans during the course of the 16-week treatment. Participants (total n=100; 70% male) who received naltrexone during the 16-week treatment trial (n=51) were compared to those who received placebo (n=49), controlling for acamprosate and behavioral intervention. Results did not support the efficacy of naltrexone on percent days abstinent, time to first heavy drinking day, and global clinical outcome in this subsample of African Americans. These results suggest that further work is needed to test naltrexone, as well as other medications, in this population and to identify treatment responders via genetics or other psychosocial predictor variables. Implications for pharmacogenetic studies of naltrexone are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.