ReviewTrends in genetics : TIG2009
Robustness: mechanisms and consequences.
Review in Trends in genetics : TIG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
184 citing papers in PubMed.
- Review
- Surface Composition and Temperature Interact to Shape Viral Survival and Growth.Environmental microbiology · 2026Article
- Transcriptional feedback targeting Wnt pathway components reveals hidden heterogeneity in Caenorhabditis elegans seam cell lineages.Genetics · 2026Article
- Spliceosome buffers cryptic genetic variation to enforce phenotypic robustness inScience advances · 2026Article
- Dynamics of Expression Variability Contribute to Retention of Small-Scale vs. Whole-Genome Duplicates.Genome biology and evolution · 2026Article
- Environmental perturbation increases gene expression variability and unmasks genetic regulation for transcriptional robustness.bioRxiv : the preprint server for biology · 2026Article
- Using machine learning to predict and analyze complex trait diseases: Lessons from a simple abstract model.PloS one · 2026Article
- Beyond efficiency: The multi-scale architecture of robust water transport in plants.Quantitative plant biology · 2026Review
- Canalization of circuit assembly by δ-protocadherins in the zebrafish optic tectum.bioRxiv : the preprint server for biology · 2025Article
- Data-driven discovery of the interplay between genetic and environmental factors in bacterial growth.Communications biology · 2024Article
- Paralogous Gene Recruitment in Multiple Families Constitutes Genetic Architecture and Robustness of Pod Dehiscence in Legumes.Genome biology and evolution · 2024Article
- Associations Between Developmental Stability, Canalization, and Phenotypic Plasticity in Response to Heterogeneous Experience.Ecology and evolution · 2024Article
- Formalizing the law of diminishing returns in metabolic networks using an electrical analogy.Royal Society open science · 2024Article
- Robustness quantification of a mutant library screen revealed key genetic markers in yeast.Microbial cell factories · 2024Article
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signalling networks.Proceedings. Biological sciences · 2024Article
- Mutational robustness and the role of buffer genes in evolvability.The EMBO journal · 2024Review
- Variability in Neural Circuit Formation.Cold Spring Harbor perspectives in biology · 2024Review
- Self-replicating artificial neural networks give rise to universal evolutionary dynamics.PLoS computational biology · 2024Article
- Robust axis elongation by Nodal-dependent restriction of BMP signaling.Development (Cambridge, England) · 2024Article
- Article
124 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Biological systems are robust to perturbation by mutations and environmental fluctuations. New data are shedding light on the biochemical and network-level mechanisms responsible for robustness. Robustness to mutation might have evolved as an adaptation to reduce the effect of mutations, as a congruent byproduct of adaptive robustness to environmental variation, or as an intrinsic property of biological systems selected for their primary functions. Whatever its mechanism or origin, robustness to mutation results in the accumulation of phenotypically cryptic genetic variation. Partial robustness can lead to pre-adaptation, and thereby might contribute to evolvability. The identification and characterization of phenotypic capacitors - which act as switches of the degree of robustness - are critical to understanding the mechanisms and consequences of robustness.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.