Evidence map›Paper›PMID 19716990›Full record

ReviewThe Psychiatric clinics of North America2009

The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology.

Elizabeth I Martin, Kerry J Ressler, Elisabeth Binder, Charles B Nemeroff

Registry-linked trialAbstract readReview
In one paragraph

Review in The Psychiatric clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 194 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  4. Effectiveness of telemedicine-based psychosocial intervention for breast cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  6. The Age of Onset of Anxiety Disorders.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017
    Pooled it
  7. Meta-analysis of P300 waveform in panic disorder.Experimental brain research · 2014
    Pooled it
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth I MartinLaboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA. eimarti@emory.edu
Kerry J Ressler
Elisabeth Binder
Charles B Nemeroff

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Signal transductionP50MH058922 · NIMH · EMORY UNIVERSITY · PI SANCHEZ, MAR M · 1999 to 2008
$21.7M
Projevt 5: Effects of the CRF1 receptor antagonist in patients w/PTSD: a plcebocoU19MH069056 · NIMH · EMORY UNIVERSITY · PI BINDER, ELIZABETH · 2003 to 2013
$15.4M
Special Scientific Procedures: Statistical Modeling CoreP50MH077083 · NIMH · EMORY UNIVERSITY · PI MAYBERG, HELEN S · 2006 to 2010
$9.3M
Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
THE PSYCHOBIOLOGY OF CORTICOTROPIN-RELEASING FACTORR01MH042088 · NIMH · EMORY UNIVERSITY · PI OWENS, MICHAEL JOSEPH · 1987 to 2008
$2.8M
Molecular Regulation of GABA(A) Receptor Function in AmygdalaR01DA019624 · NIDA · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2006 to 2010
$1.8M
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
NCATS NIH HHS UL1 TR000454NCRR NIH HHS UL1 RR025008NIDA NIH HHS DA-019624NIDA NIH HHS R01 DA019624NIMH NIH HHS MH071537NIMH NIH HHS MH-42088NIMH NIH HHS MH-541380NIMH NIH HHS MH-58922NIMH NIH HHS MH-69056NIMH NIH HHS MH-77083NIMH NIH HHS P50 MH058922NIMH NIH HHS P50 MH077083NIMH NIH HHS R01 MH042088NIMH NIH HHS R01 MH071537NIMH NIH HHS R56 MH071537NIMH NIH HHS U19 MH069056
6 · The paper itself

Abstract

Anxiety disorders are highly comorbid with each other and with major depressive disorder. As syndromes, anxiety and mood disorders share many symptoms, and several treatments are effective for both. Despite this overlap, there exist many distinguishing features that support the continued classification of individual anxiety disorders that are distinct from each other and from major depression. The goal of this article is to describe the key biological similarities and differences between anxiety disorders.

Indexed as

Diagnostic ImagingGenetic Predisposition to DiseaseAnxiety DisordersBrainEmotionsHumansModels, NeurologicalMood DisordersNeurosecretory SystemsPanic DisorderStress Disorders, Post-TraumaticSynaptic Transmission

Identifiers

PMID19716990
PMCPMC3684250

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.