ArticleExperimental hematology2009
Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma.
Article in Experimental hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The NF-κB Nucleolar Stress Response Pathway.Biomedicines · 2021Review
- Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.Scientific reports · 2019Article
- Article
- Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus.Biomedicines · 2017Review
- Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer.World journal of gastroenterology · 2016Review
- Neurotrophins and B-cell malignancies.Cellular and molecular life sciences : CMLS · 2016Review
- Anti-apoptotic role and clinical relevance of neurotrophins in diffuse large B-cell lymphomas.British journal of cancer · 2015Article
- Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.Experimental hematology · 2015Article
- Article
- Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke.Journal of cellular and molecular medicine · 2012Review
- Cellular elements of the subarachnoid space promote ALL survival during chemotherapy.Leukemia research · 2011Article
- Article
- Linking molecules to mood: new insight into the biology of depression.The American journal of psychiatry · 2010Review
- Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.Molecular cancer therapeutics · 2010Article
- Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat.Mediators of inflammation · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNeurotrophin receptor signaling has been increasingly recognized as an important factor in the development and progression of a variety of malignancies. In order to analyze the potential contribution of neurotrophin signaling to lymphoma cell survival, we investigated the role of a neurotrophin axis in promoting survival and proliferation of non-Hodgkin lymphoma (NHL) cells. MATERIALS AND
methodsThe role of neurotrophins in the survival and proliferation of NHL cells was determined by exposing cells to the Trk-specific inhibitor, K252a, and then performing (3)H-thymidine incorporation and Annexin-V/propidium iodide staining. The involvement of nuclear factor-kappaB (NF-kappaB) in this process was studied using Western blot, electrophoretic mobility shift assay, and immunofluorescence assays.
resultsHere we demonstrate that both primary NHL cells and diffuse large B-cell lymphoma cell lines express Trk receptors and their neurotrophin ligands. Furthermore, these cells are sensitive to the Trk-specific inhibitor, K252a, as evidenced by the inhibition of proliferation and/or induction of apoptosis. Analysis of the mechanism into the effects of K252a revealed that, in the OCI-LY3 cell line, K252a induced a subnuclear distribution of NF-kappaB resulting in the sequestration of RelA in the nucleolus, thereby inhibiting NF-kappaB-dependent gene transcription. This results in the loss of interleukin-6 production; a known survival-promoting signal for OCI-LY3, as well as many primary diffuse large B-cell lymphomas.
conclusionThus, Trk receptors represent a novel therapeutic target for the treatment of NHL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.