ArticleDevelopmental biology2009
Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Generation of Hoxa11-3XFLAG and Hoxd11-3XFLAG alleles to investigate Hox11 genome-wide binding.Developmental biology · 2025Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.Frontiers in cell and developmental biology · 2021Review
- The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology.Frontiers in cell and developmental biology · 2021Review
- Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.PLoS genetics · 2018Article
- Article
- A new frontonasal dysplasia syndrome associated with deletion of the SIX2 gene.American journal of medical genetics. Part A · 2016Article
- Hox genes and evolution.F1000Research · 2016Review
- Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.Development (Cambridge, England) · 2015Article
- Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.BMC developmental biology · 2015Article
- Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons.PLoS genetics · 2013Article
- Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.Developmental cell · 2012Article
- Hox transcription factors influence motoneuron identity through the integrated actions of both homeodomain and non-homeodomain regions.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Defining and redefining the nephron progenitor population.Pediatric nephrology (Berlin, Germany) · 2011Review
- Hox genes and kidney development.Pediatric nephrology (Berlin, Germany) · 2011Review
- Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.Molecular and cellular biology · 2011Article
- Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.PloS one · 2011Article
- Hox genes and regional patterning of the vertebrate body plan.Developmental biology · 2010Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hox genes control many developmental events along the AP axis, but few target genes have been identified. Whether target genes are activated or repressed, what enhancer elements are required for regulation, and how different domains of the Hox proteins contribute to regulatory specificity are poorly understood. Six2 is genetically downstream of both the Hox11 paralogous genes in the developing mammalian kidney and Hoxa2 in branchial arch and facial mesenchyme. Loss-of-function of Hox11 leads to loss of Six2 expression and loss-of-function of Hoxa2 leads to expanded Six2 expression. Herein we demonstrate that a single enhancer site upstream of the Six2 coding sequence is responsible for both activation by Hox11 proteins in the kidney and repression by Hoxa2 in the branchial arch and facial mesenchyme in vivo. DNA-binding activity is required for both activation and repression, but differential activity is not controlled by differences in the homeodomains. Rather, protein domains N- and C-terminal to the homeodomain confer activation versus repression activity. These data support a model in which the DNA-binding specificity of Hox proteins in vivo may be similar, consistent with accumulated in vitro data, and that unique functions result mainly from differential interactions mediated by non-homeodomain regions of Hox proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.