ArticleActa biomaterialia2010
Synthesis and characterization of thermoresponsive polyamidoamine-polyethylene glycol-poly(D,L-lactide) core-shell nanoparticles.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Engineered Multifunctional Drug-Loaded Dendrimer Nanoparticles for Glaucoma: Triple Mechanism via Antioxidant Activity, Iron Chelation, and Enhanced Ocular Transport.Biomacromolecules · 2025Article
- Drug-Conjugated Dendrimer Hydrogel Enables Sustained Drug Release via a Self-Cleaving Mechanism.Molecular pharmaceutics · 2019Article
- Antibacterial Activity of Nitric Oxide-Releasing Hyperbranched Polyamidoamines.Bioconjugate chemistry · 2018Article
- Electrospinning of PEGylated polyamidoamine dendrimer fibers.Materials science & engineering. C, Materials for biological applications · 2015Article
- Cyclic peptide-selenium nanoparticles as drug transporters.Molecular pharmaceutics · 2014Article
- Click hybridization of immune cells and polyamidoamine dendrimers.Advanced healthcare materials · 2014Article
- Electrospun blends of gelatin and gelatin-dendrimer conjugates as a wound-dressing and drug-delivery platform.Biomacromolecules · 2013Article
- Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters.Molecular pharmaceutics · 2013Article
- Poly (ethylene glycol)-armed hyperbranched polyoxetanes for anticancer drug delivery.Journal of bioactive and compatible polymers · 2012Article
- Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis.Pharmaceutical research · 2010Review
- PEGylated polyamidoamine dendrimers with bis-aryl hydrazone linkages for enhanced gene delivery.Biomacromolecules · 2010Article
- Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery.Biomacromolecules · 2010Article
- Surface engineering of macrophages with nanoparticles to generate a cell-nanoparticle hybrid vehicle for hypoxia-targeted drug delivery.International journal of nanomedicine · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA. The ninhydrin assay, (1)H NMR, Fourier transform infrared spectroscopy, dynamic light scattering and atomic force microscopy were used to characterize the structure and compositions of dendritic PEG-PDLLA nanoparticles. The sol-gel phase transition of aqueous dendritic PEG-PDLLA solutions was measured using UV-visual spectroscopy. According to our results dendritic PEG-PDLLA nanoparticles in aqueous solution can self-assemble into sub-micron/micron aggregates, the size of which is dependent on temperature and PEG-PDLLA chain length. Further, dendritic PEG-PDLLA solutions exhibit a sol-gel phase transition with increasing temperature. The constructed dendritic PEG-PDLLA nanoparticles possessed high cytocompatibility, which was significantly improved compared with PAMAM dendrimers. The potential of dendritic PEG-PDLLA nanoparticles for encapsulation of water-insoluble drugs such as camptothecin was demonstrated. The dendritic PEG-PDLLA nanoparticles we developed offer greater structural flexibility and provide a novel nanostructured thermoresponsive carrier for drug delivery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.