ArticleJournal of insect physiology2010
Functional consequences of mutations in the Drosophila histamine receptor HCLB.
Article in Journal of insect physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents.Pest management science · 2026Article
- Regulation of diel locomotor activity and retinal responses of Anopheles stephensi by ingested histamine and serotonin is temperature- and infection-dependent.PLoS pathogens · 2025Article
- A Closer Look at Histamine inInternational journal of molecular sciences · 2024Review
- Glutamate-gated chloride channels.The Journal of biological chemistry · 2012Review
- Participation of the histamine receptor encoded by the gene hclB (HCLB) in visual sensitivity control: an electroretinographic study in Drosophila melanogaster.Molecular vision · 2012Article
- Effect of ivermectin on the integument and dorsoventral muscles of the tick Argas (Persicargas) persicus (Oken) (Ixodoidea: Argasidae).Parasitology research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The gene hclB encodes a histamine-gated chloride channel subunit in Drosophila melanogaster. Mutations in hclB lead to defects in the visual system and altered sensitivity to the action of ivermectin. To investigate whether this member of the Cys-loop receptors is common across the Insecta, we analysed the genomes of seven other insect species (Diptera, Hymenoptera, Coleoptera) and revealed orthologues of hclB in all of them. Sequence comparisons showed high identity levels between the orthologues, indicating similar constraints and conserved function between the species. Two D. melanogaster mutants, hclB(T1) (P293S) and hclB(T2) (W111*, a null mutation) were tested for the lapse into, and recovery from, paralysis induced by high temperature or the anaesthetic action of halothane. At 41 degrees C, the hclB(T2) flies lapsed into coma faster than wild-type or the hclB(T1) flies, while both mutants recovered more slowly. A substantially impaired recovery rate was also observed in hclB(T1) after anaesthesia with halothane. Enhanced synaptic signalling at low-intensity light stimuli was registered on electroretinograms recorded from the two mutant strains. Our results suggest that HCLB may play an essential and conserved role in insect neurophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.