ReviewTrends in neurosciences2009
Air pollution: mechanisms of neuroinflammation and CNS disease.
Review in Trends in neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 697 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
697 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,582 citations in OpenAlex.
- The Effects of Air Pollutants on Antenatal and Postpartum Depression: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2025Pooled it
- Small extracellular vesicles: connecting early life exposure outcomes to air pollution during pregnancy to early childhood health.Environmental health : a global access science source · 2025Pooled it
- Air pollution and sleep health in middle-aged and older adults: A systematic review and meta-analysis.Sleep medicine reviews · 2025Pooled it
- Gasotransmitters and their influence on autism spectrum disorders - a systematic review.Molecular biology reports · 2025Pooled it
- Air pollution: a latent key driving force of dementia.BMC public health · 2024Pooled it
- Urban PMMolecular neurobiology · 2026Article
- Review
- The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson's disease and all-cause mortality risks and transitions: The UK Biobank study.Ecotoxicology and environmental safety · 2026Article
- Review
- Air pollution and cognitive outcomes in older adults: a systematic review.Reviews on environmental health · 2026Review
- Can the use of clean energy improve the cognitive ability of the rural elderly? Evidence from clean heating policy in northern China.BMC geriatrics · 2026Article
- Biomimetic Chromatography Profiling of a Neurotoxicology-Relevant Compound Panel: A Physicochemical Dataset for New Approach Methodologies.Biomimetics (Basel, Switzerland) · 2026Article
- Impacts of contemporaneous air pollution exposure on cognitive performance in Kenya.Journal of health economics · 2026Article
- Prenatal Exposure to Ambient Particulate Matter and Autism Spectrum Disorder in Children, a Case Control Study in France.Journal of autism and developmental disorders · 2026Observational
- Environmental particulate reference materials increase DCFDA fluorescence and reduce ATP-dependent viability in primary mouse retinal cells.Biochemistry and biophysics reports · 2026Article
- The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- PMiScience · 2026Review
- Effects of Recent Air Pollution Exposure on Children's Neurocognitive Functions and the Possible Link with Endothelial Function.International journal of environmental research and public health · 2026Article
- Climate Change, Neurological Disorders and Brain Health: To-Know Concepts and Future Actions by the EAN Environmental Influences in Neurology Task Force.European journal of neurology · 2026Review
- Characterizing the relationship between air pollution and childhood cognition in the Children's health and air pollution study.Environmental research · 2026Article
637 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Air pollution has been implicated as a chronic source of neuroinflammation and reactive oxygen species (ROS) that produce neuropathology and central nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's disease pathology are linked to air pollution. Recent reports reveal that air pollution components reach the brain; systemic effects that impact lung and cardiovascular disease also impinge upon CNS health. While mechanisms driving air pollution-induced CNS pathology are poorly understood, new evidence suggests that microglial activation and changes in the blood-brain barrier are key components. Here we summarize recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS, culminating in CNS disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.