ArticleBiological psychology2010
Serotonin transporter gene promoter region polymorphism and selective processing of emotional images.
Article in Biological psychology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Genetics moderate alcohol and intimate partner violence treatment outcomes in a randomized controlled trial of hazardous drinking men in batterer intervention programs: A preliminary investigation.Journal of consulting and clinical psychology · 2016Trial
- The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene.Biological psychiatry · 2011Trial
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.Journal of neuroscience research · 2017Review
- Serotonin 5-HTTLPR Genotype Modulates Reactive Visual Scanning of Social and Non-social Affective Stimuli in Young Children.Frontiers in behavioral neuroscience · 2017Article
- Attentional biases to emotional stimuli: Key components of the RDoC constructs of sustained threat and loss.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- 5-HTTLPR, HTR1A, and HTR2A cumulative genetic score interacts with mood reactivity to predict mood-congruent gaze bias.Cognitive, affective & behavioral neuroscience · 2014Article
- Genetic associations with intimate partner violence in a sample of hazardous drinking men in batterer intervention programs.Violence against women · 2014Article
- 5-HTTLPR modulates the recognition accuracy and exploration of emotional facial expressions.Frontiers in behavioral neuroscience · 2014Article
- The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood.Development and psychopathology · 2013Article
- Toward an integration of cognitive and genetic models of risk for depression.Cognition & emotion · 2013Review
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
- Genetic moderation of sensitivity to positive and negative affect in marriage.Emotion (Washington, D.C.) · 2012Article
- 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.PloS one · 2012Article
- Eye-tracking with nonhuman primates is now more accessible than ever before.American journal of primatology · 2011Article
- Affective cognition and its disruption in mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Association between 5-HTTLPR and Borderline Personality Disorder Traits among Youth.Frontiers in psychiatry · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Several studies have now documented that the serotonin transporter promoter region (5-HTTLPR) polymorphism predicts neural response to affective images in brain regions involved in the experience of emotion. However, the behavioral consequences of this genetic effect are less well known. The current study used eye-tracking methodology to examine how individuals genotyped for the 5-HTTLPR allocated their attention when simultaneously presented an array of positive and negative emotional scenes. Short 5-HTTLPR allele homozygotes displayed a bias to focus on positive images, particularly in the first half of the 30s trial. In contrast, long 5-HTTLPR allele homozygotes viewed the stimuli in a more evenhanded fashion. Thus, short 5-HTTLPR allele homozygotes may be attempting to regulate greater reactivity to negative stimuli by purposefully turning their attention towards positive stimuli. Although this sensitivity may have benefits under benign conditions, it may also increase vulnerability to affective disorders when cognitive resources needed to turn attention away from negative stimuli are compromised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.