ReviewJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2009
Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.
Review in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Commentary on "Poor evidence for host-dependent regular RNA editing in the transcriptome of SARS-CoV-2".Journal of applied genetics · 2022Article
- Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations.RNA (New York, N.Y.) · 2022Review
- Quantification of Type I Interferon Inhibition by Viral Proteins: Ebola Virus as a Case Study.Viruses · 2021Article
- Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2.Science advances · 2020Article
- Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR.The Journal of biological chemistry · 2019Article
- Article
- The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production.Virology · 2017Article
- Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase.PLoS pathogens · 2016Article
- A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection.Scientific reports · 2015Article
- ADAR1 deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions.Cell death and differentiation · 2014Article
- How Ebola virus counters the interferon system.Zoonoses and public health · 2012Review
- A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.PloS one · 2012Article
- The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR.Journal of virology · 2011Article
- Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.Journal of virology · 2011Review
- Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection.Virology · 2011Article
- Protein kinase R as mediator of the effects of interferon (IFN) gamma and tumor necrosis factor (TNF) alpha on normal and dysplastic hematopoiesis.The Journal of biological chemistry · 2011Article
- Innate immune evasion mediated by the Ambystoma tigrinum virus eukaryotic translation initiation factor 2alpha homologue.Journal of virology · 2011Article
- The interferon stimulated gene 54 promotes apoptosis.The Journal of biological chemistry · 2011Article
- Adenosine deaminases acting on RNA, RNA editing, and interferon action.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The protein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA (ADAR1) are interferon-inducible enzymes that play important roles in biologic processes including the antiviral actions of interferons, signal transduction, and apoptosis. PKR catalyzes the RNA-dependent phosphorylation of protein synthesis initiation factor eIF-2 alpha, thereby leading to altered translational patterns in interferon-treated and virus-infected cells. PKR also modulates signal transduction responses, including the induction of interferon. ADAR1 catalyzes the deamination of adenosine (A) to generate inosine (I) in RNAs with double-stranded character. Because I is recognized as G instead of A, A-to-I editing by ADAR1 can lead to genetic recoding and altered RNA structures. The importance of PKR and ADAR1 in innate antiviral immunity is illustrated by a number of viruses that encode either RNA or protein viral gene products that antagonize PKR and ADAR1 enzymatic activity, localization, or stability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.