ArticleJournal of proteome research2009
Liver proteome analysis in a rodent model of alcoholic steatosis.
Article in Journal of proteome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Peroxiredoxin 6 in Stress Orchestration and Disease Interplay.Antioxidants (Basel, Switzerland) · 2025Review
- 4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases.Nutrients · 2024Review
- Vegetable Oil-Peroxidation Product 'Hydroxynonenal' Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver.Nutrients · 2023Article
- Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.Current opinion in toxicology · 2019Article
- Proteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and altered cysteine metabolic pathways.Physiological genomics · 2018Article
- SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice.Scientific reports · 2018Article
- Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity.Frontiers in genetics · 2018Article
- Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.PloS one · 2018Article
- Proteomic Profiling of Liver and Plasma in Chronic Ethanol Feeding Model of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice.Alcoholism, clinical and experimental research · 2017Article
- Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.World journal of gastroenterology · 2016Review
- Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE).Frontiers in chemistry · 2016Article
- Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms.Particle and fibre toxicology · 2015Article
- Changes of the Cytoplasmic Proteome in Response to Alcoholic Hepatotoxicity in Rats.International journal of molecular sciences · 2015Article
- Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis.PloS one · 2015Article
- Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.PloS one · 2014Article
- Liver proteomics in progressive alcoholic steatosis.Toxicology and applied pharmacology · 2013Article
- The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: a proteomic study.BMC biochemistry · 2012Article
- A dynamic plasma membrane proteome analysis of alcohol-induced liver cirrhosis.Proteome science · 2012Article
- Protein carbonylation in a murine model for early alcoholic liver disease.Chemical research in toxicology · 2012Article
- A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.Proteome science · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease (ALD) and is characterized by the accumulation of fat in the liver. AS is considered clinically benign because it is reversible, and the progression of AS to alcoholic steatohepatitis (ASH) is a key step in the development of ALD. A two-dimensional gel electrophoresis (2DE)-mass spectrometry (MS) proteomic approach was used to investigate the protein expression pattern underlying AS, as the first step toward determining liver tissue biomarkers for early stage ALD. Several proteins involved in fatty acid and amino acid metabolism were up-regulated in 3- and 6-week ethanol-fed rats relative to isocaloric controls, which suggest a higher energy demand upon chronic exposure to ethanol. In addition, the expression of two proteins associated with alcohol-induced oxidative stress, peroxiredoxin 6 (PRDX6) and aldehyde dehydrogenase 2 (ALDH2), was down-regulated in ethanol fed rats, and suggests an increase in reactive oxygen species and oxidative stress. To investigate if irreversible protein modification arising from oxidative stress during AS impacts protein levels, the extent of carbonylated proteins in the ethanol and isocaloric groups was identified using mass spectrometry. The detection of modified proteins involved in antioxidant functions further supports the notion that oxidative modification of these proteins leads to protein turnover during AS. In addition, the carbonylation of betaine-homocysteine S-methyltransferase, a protein implicated in fatty liver development, in 3-week and 6-week ethanol exposed samples suggests that this protein could be a marker for early stage AS.
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