ArticleAngewandte Chemie (International ed. in English)2009
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality.
Article in Angewandte Chemie (International ed. in English), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 990 papers.
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Who cites it
990 citing papers in PubMed.
- Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics.Chembiochem : a European journal of chemical biology · 2026Review
- Evidence for a Cu(II)-Catalysed CuAAC Reaction: A Combined Experimental and Computational Study.Angewandte Chemie (International ed. in English) · 2026Article
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- Biomolecule-polymer conjugates synthesized by a combination of organometallic bioconjugation and atom transfer radical polymerization.Polymer chemistry · 2026Article
- Step-by-Step Protocol for Fluorescence-Based Analysis of Uptake in Transporter-ExpressingBio-protocol · 2026Article
- ShimNetV2-RM Neural Network for Post-Acquisition Correction of Spectral Lineshapes in NMR Reaction Monitoring.Magnetic resonance in chemistry : MRC · 2026Article
- Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters.Angewandte Chemie (International ed. in English) · 2026Article
- Site-Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids.Angewandte Chemie (International ed. in English) · 2026Review
- Bioorthogonal chemistry for deciphering lipid biology in living systems.RSC chemical biology · 2026Review
- Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates.Chemical science · 2026Article
- Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.Nature microbiology · 2026Article
- Strain-Accelerated β-Thiolactone Native Chemical Ligation with Kinetic Control Enables Rapid and Selective Hydrogelation for Biofabrication.Journal of the American Chemical Society · 2026Article
- Protein Modifications for Cellular Protein Delivery.Chemical reviews · 2026Review
- Photo-Triggered, Fast, and Fluorogenic Thiophene-Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3-Dipole-Tagged Molecules in No-Wash Conditions.Angewandte Chemie (International ed. in English) · 2026Article
- Evaluating the endothelial glycocalyx from bench to bedside: a translational framework for microvascular assessment.Angiogenesis · 2026Review
- Metabolic Labeling of Phosphatidylethanolamine Lipids in Cells Using Clickable Ethanolamine Analogs.Chembiochem : a European journal of chemical biology · 2026Article
- Hydrogels: current biomedical applications and future directions.Molecular biomedicine · 2026Review
- Single-Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco-Immune Checkpoints, and Tumor-Immune Communication.Advanced biology · 2026Review
- Programmable nanomedicine via bioorthogonal molecular engineering.Nano convergence · 2026Review
- Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction.Angewandte Chemie (International ed. in English) · 2026Article
930 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
The study of biomolecules in their native environments is a challenging task because of the vast complexity of cellular systems. Technologies developed in the last few years for the selective modification of biological species in living systems have yielded new insights into cellular processes. Key to these new techniques are bioorthogonal chemical reactions, whose components must react rapidly and selectively with each other under physiological conditions in the presence of the plethora of functionality necessary to sustain life. Herein we describe the bioorthogonal chemical reactions developed to date and how they can be used to study biomolecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.