ArticleMolecular biology reports2010
Mutations of MC4R gene and its association with economic traits in Qinchuan cattle.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- A conserved functional missense SNP (E100K) in sheep MC4R gene leading to functional loss and impacting the growth traits.Journal of animal science · 2026Article
- Innovations in Cattle Breeding Technology: Prospects in the Era of Gene Editing.Animals : an open access journal from MDPI · 2025Review
- A Critical Functional Missense Mutation (T117M) in SheepAnimals : an open access journal from MDPI · 2024Article
- Allelic and genotypic frequencies of SNP related to beef and carcass quality in Romosinuano cattle in Mexico.Tropical animal health and production · 2023Article
- Two co-inherited novel SNPs in the MC4R gene related to live body weight and hormonal assays in Awassi and Arabi sheep breeds of Iraq.Veterinary medicine and science · 2021Article
- Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle.Frontiers in physiology · 2018Article
- Melanocortin-4 receptor (MC4R) polymorphisms are associated with growth and meat quality traits in sheep.Molecular biology reports · 2014Article
- SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs.Experimental animals · 2014Article
- Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.Journal of applied genetics · 2013Review
- Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle.Molecular biology reports · 2013Article
- BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.Molecular biology reports · 2012Article
- Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).Molecular biology reports · 2012Article
- Molecular characterization of CART, AgRP, and MC4R genes and their expression with fasting and re-feeding in common carp (Cyprinus carpio).Molecular biology reports · 2012Article
- Single nucleotide polymorphism of CACNA2D1 gene and its association with milk somatic cell score in cattle.Molecular biology reports · 2011Article
- Cloning and characterization of the 5'-flanking region of the pig AgRP gene.Molecular biology reports · 2011Article
- Three novel SNPs in the coding region of PPARγ gene and their associations with meat quality traits in cattle.Molecular biology reports · 2011Article
- A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows.Molecular biology reports · 2011Article
- Polymorphism of DLK1 and CLPG gene and their association with phenotypic traits in Chinese cattle.Molecular biology reports · 2011Article
- Novel SNPs of the bovine CACNA2D1 gene and their association with carcass and meat quality traits.Molecular biology reports · 2011Article
- Polymorphism of bovine Y-STR UMN0929 and its correlation with carcass traits in five Chinese beef cattle populations.Molecular biology reports · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MC4R belongs to a seven-transmembrane G-protein-coupled receptor which may regulate body composition and insulin action. Many mutations in the MC4R gene are associated with obesity, energy expenditure and serum triglyceride levels in human and animals. Six mutations in the MC4R gene were identified in our study (-293C>G, -193A>T, -192T>G, -129A>G, -84T>C and 1,069C>G). The -129A>G was significantly associated with live weight (LW) (P < 0.05), Cattle with the genotypes AG and GG had higher LW than genotype AA. The 1,069C>G was significantly associated with LW, carcass weight (CW), backfat thickness and marbling score (MS). Cattle with the genotype GG had higher LW, CW and MS than genotype CC; Cattle with the genotypes GG and CG had higher MS than CC. The results suggested that -129A>G and 1,069C>G SNP of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
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