ArticleMolecular biology reports2010
Single nucleotide polymorphisms in bovine PRL gene and their associations with milk production traits in Chinese Holsteins.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 45 citations in OpenAlex.
- Polymorphism of theVeterinary sciences · 2023Article
- The Role of PRLR Gene Polymorphisms in Milk Production in European Wild Rabbit (Animals : an open access journal from MDPI · 2023Article
- Association analysis of single-nucleotide polymorphism in prolactin and its receptor with productive and body conformation traits in Liaoning cashmere goats.Archives animal breeding · 2022Article
- Genetic analysis of prolactin gene in Pakistani cattle.Molecular biology reports · 2013Article
- Single nucleotide polymorphisms, haplotypes and combined genotypes of LAP3 gene in bovine and their association with milk production traits.Molecular biology reports · 2011Article
- Study on polymerization effect of polyembryony genes by SSCP marker and family trees in Chinese goats.Molecular biology reports · 2011Article
- Characterization of the GHR gene genetic variation in Chinese indigenous goat breeds.Molecular biology reports · 2011Article
- Novel SNPs of butyrophilin (BTN1A1) and milk fat globule epidermal growth factor (EGF) 8 (MFG-E8) are associated with milk traits in dairy goat.Molecular biology reports · 2011Article
- Correlation analysis between three novel SNPs of the Src gene in bovine and milk production traits.Molecular biology reports · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Prolactin (PRL) plays a crucial role in the initiation and maintenance of lactation in mammals. In this study, seven PCR fragments representing most important functional domains of PRL gene were screened for single nucleotide polymorphisms (SNPs) in Chinese Holsteins by single-strand conformation polymorphisms and amplicons sequencing, and their genetic effects on milk production traits were evaluated. A total of four SNPs, including two in the promoter (-1043A>G and -402A>G), one in intron 1 (+2723C>T) and one in exon 4 (+8398G>A) were identified in PRL gene. Statistical results showed significant associations between the promoter genotypes and the milk performance traits in Chinese Holsteins. Cows with genotype P1-GG showed higher milk yields (P < 0.01), while cows with genotype P1-AA showed higher fat contents (P < 0.01). Haplotype analysis of two SNPs in promoter region revealed that the Hap(AG) was significantly associated with increased milk yields and Hap(AA) was associated with increased fat contents (P < 0.01). This is the second study reporting SNPs in the 5'-regulatory region of PRL gene, which interfere with milk production traits.
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